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• W2023138638 endingPage "58" @default.
• W2023138638 startingPage "54" @default.
• W2023138638 abstract "Genetic studies undertaken in the model organism Caenorhabditis elegans have demonstrated the importance of neuropeptidergic signalling in nematode physiology. Disruption of this signalling may have deleterious phenotypic consequences, including altered locomotion, feeding behaviour, and reproduction. Neuropeptide G protein-coupled receptors (GPCRs) that transduce many of these signals therefore represent cogent drug targets. Recently published genomic sequencing data for a number of parasitic helminths of medical and veterinary importance has revealed the apparent conservation of a number of neuropeptides, and neuropeptide receptors between parasitic and free-living species, raising the intriguing possibility of developing broad-spectrum anthelmintic therapeutics. Here, we identify and clone a neuropeptide receptor, NPR-4, from the human filarial nematode Brugia malayi and demonstrate its activation in vitro, by FMRFamide-like peptides of the FLP-18 family, and intracellular signalling via Gαi mediated pathways. These data represent the first example of deorphanisation of a neuropeptide GPCR in any parasitic helminth species." @default.
• W2023138638 created "2016-06-24" @default.
• W2023138638 creator A5008299987 @default.
• W2023138638 creator A5073165630 @default.
• W2023138638 creator A5074801878 @default.
• W2023138638 creator A5085743042 @default.
• W2023138638 date "2014-06-01" @default.
• W2023138638 modified "2023-10-16" @default.
• W2023138638 title "The Brugia malayi neuropeptide receptor-4 is activated by FMRFamide-like peptides and signals via Gαi" @default.
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• W2023138638 doi "https://doi.org/10.1016/j.molbiopara.2014.07.002" @default.
• W2023138638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25038481" @default.
• W2023138638 hasPublicationYear "2014" @default.
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