Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023139469> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2023139469 endingPage "S82" @default.
- W2023139469 startingPage "S81" @default.
- W2023139469 abstract "Multiple molecular resistance mechanisms reduce the efficiency of receptor tyrosine kinase inhibitors such as gefitinib in non-small cell lung cancer (NSCLC). We previously demonstrated that amphiregulin (Areg) inhibits gefitinib-induced apoptosis in NSCLC cells by inactivating the proapoptotic protein BAX. In this part of the investigation, we studied the molecular mechanisms leading to BAX inactivation. We show that Areg prevents gefitinib-mediated acetylation of Ku70. This augments the BAX-Ku70 interaction and therefore prevents BAX-mediated apoptosis. Accordingly, Areg or Ku70 knock down restore BAX activation and apoptosis in gefitinib-treated H358 cells in vitro. In addition, overexpression of the histone acetyltransferase (HAT) CREB-binding protein (CBP) or treatments with histone deacetylase (HDAC) inhibitors sensitize H358 cells to gefitinib. Moreover, a treatment with vorinostat, a HDAC inhibitor strongly sensitized tumors to gefitinib in vivo. These findings suggest new prospects in combining both HDAC and epidermal growth factor receptor inhibitors for the treatment of NSCLC." @default.
- W2023139469 created "2016-06-24" @default.
- W2023139469 creator A5023993622 @default.
- W2023139469 creator A5027068255 @default.
- W2023139469 creator A5030455508 @default.
- W2023139469 creator A5050598034 @default.
- W2023139469 creator A5052386944 @default.
- W2023139469 creator A5053063756 @default.
- W2023139469 creator A5053712155 @default.
- W2023139469 creator A5080124249 @default.
- W2023139469 creator A5083568952 @default.
- W2023139469 date "2010-03-01" @default.
- W2023139469 modified "2023-09-27" @default.
- W2023139469 title "101: Identification of differential pathways in mucinous and non-mucinous subtypes of lung adenocarcinoma suggested new therapeutic strategies" @default.
- W2023139469 doi "https://doi.org/10.1016/s0007-4551(15)31194-2" @default.
- W2023139469 hasPublicationYear "2010" @default.
- W2023139469 type Work @default.
- W2023139469 sameAs 2023139469 @default.
- W2023139469 citedByCount "2" @default.
- W2023139469 crossrefType "journal-article" @default.
- W2023139469 hasAuthorship W2023139469A5023993622 @default.
- W2023139469 hasAuthorship W2023139469A5027068255 @default.
- W2023139469 hasAuthorship W2023139469A5030455508 @default.
- W2023139469 hasAuthorship W2023139469A5050598034 @default.
- W2023139469 hasAuthorship W2023139469A5052386944 @default.
- W2023139469 hasAuthorship W2023139469A5053063756 @default.
- W2023139469 hasAuthorship W2023139469A5053712155 @default.
- W2023139469 hasAuthorship W2023139469A5080124249 @default.
- W2023139469 hasAuthorship W2023139469A5083568952 @default.
- W2023139469 hasConcept C104317684 @default.
- W2023139469 hasConcept C143998085 @default.
- W2023139469 hasConcept C170493617 @default.
- W2023139469 hasConcept C185592680 @default.
- W2023139469 hasConcept C190283241 @default.
- W2023139469 hasConcept C2776256026 @default.
- W2023139469 hasConcept C2778305200 @default.
- W2023139469 hasConcept C2779438470 @default.
- W2023139469 hasConcept C2780580887 @default.
- W2023139469 hasConcept C2780806702 @default.
- W2023139469 hasConcept C502942594 @default.
- W2023139469 hasConcept C55493867 @default.
- W2023139469 hasConcept C62478195 @default.
- W2023139469 hasConcept C64927066 @default.
- W2023139469 hasConcept C71924100 @default.
- W2023139469 hasConcept C86803240 @default.
- W2023139469 hasConcept C95444343 @default.
- W2023139469 hasConceptScore W2023139469C104317684 @default.
- W2023139469 hasConceptScore W2023139469C143998085 @default.
- W2023139469 hasConceptScore W2023139469C170493617 @default.
- W2023139469 hasConceptScore W2023139469C185592680 @default.
- W2023139469 hasConceptScore W2023139469C190283241 @default.
- W2023139469 hasConceptScore W2023139469C2776256026 @default.
- W2023139469 hasConceptScore W2023139469C2778305200 @default.
- W2023139469 hasConceptScore W2023139469C2779438470 @default.
- W2023139469 hasConceptScore W2023139469C2780580887 @default.
- W2023139469 hasConceptScore W2023139469C2780806702 @default.
- W2023139469 hasConceptScore W2023139469C502942594 @default.
- W2023139469 hasConceptScore W2023139469C55493867 @default.
- W2023139469 hasConceptScore W2023139469C62478195 @default.
- W2023139469 hasConceptScore W2023139469C64927066 @default.
- W2023139469 hasConceptScore W2023139469C71924100 @default.
- W2023139469 hasConceptScore W2023139469C86803240 @default.
- W2023139469 hasConceptScore W2023139469C95444343 @default.
- W2023139469 hasIssue "1" @default.
- W2023139469 hasLocation W20231394691 @default.
- W2023139469 hasOpenAccess W2023139469 @default.
- W2023139469 hasPrimaryLocation W20231394691 @default.
- W2023139469 hasRelatedWork W2018360198 @default.
- W2023139469 hasRelatedWork W2106221413 @default.
- W2023139469 hasRelatedWork W2142774159 @default.
- W2023139469 hasRelatedWork W2395757841 @default.
- W2023139469 hasRelatedWork W2480283680 @default.
- W2023139469 hasRelatedWork W2563014202 @default.
- W2023139469 hasRelatedWork W2924811393 @default.
- W2023139469 hasRelatedWork W3109371411 @default.
- W2023139469 hasRelatedWork W4252253415 @default.
- W2023139469 hasRelatedWork W2565765257 @default.
- W2023139469 hasVolume "97" @default.
- W2023139469 isParatext "false" @default.
- W2023139469 isRetracted "false" @default.
- W2023139469 magId "2023139469" @default.
- W2023139469 workType "article" @default.