Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023140356> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2023140356 endingPage "843" @default.
- W2023140356 startingPage "835" @default.
- W2023140356 abstract "To determine the extent of neurotoxicity of parenterally administered hexacarbons, male Sprague-Dawley rats were given either n-hexane or 2,5-hexanedione for 35 consecutive days. Electrophysiologic measurements showed a lengthening of the sciatic and sural nerve action potentials (slower conduction velocities) and increased refractory periods. These effects correlated with a shift in the nerve membrane sensitivity to potassium-induced depolarization. A similar effect can be induced by ouabain, an Na+, K+-ATPase inhibitor. These effects were seen with both n-hexane and 2,5-hexane-dione. Although the treated animals gained weight more slowly than controls, they showed no loss of motor function when tested behaviorally, and there were no signs of histopathology in the peripheral nerves. These results show that hexacarbons produce a neurotoxicity that can be demonstrated by changes in nerve excitability, prior to overt behavioral neurotoxicity. Furthermore, these electrophysiologic changes may be related to a hexacarbon-induced disruption of nerve-membrane ATPase activity." @default.
- W2023140356 created "2016-06-24" @default.
- W2023140356 creator A5040725244 @default.
- W2023140356 creator A5053815447 @default.
- W2023140356 date "1984-01-01" @default.
- W2023140356 modified "2023-09-27" @default.
- W2023140356 title "Electrophysiologic deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicity" @default.
- W2023140356 cites W1970224485 @default.
- W2023140356 cites W1981058171 @default.
- W2023140356 cites W1997610473 @default.
- W2023140356 cites W2016292152 @default.
- W2023140356 cites W2022260401 @default.
- W2023140356 cites W2026181594 @default.
- W2023140356 cites W2026407117 @default.
- W2023140356 cites W2037916927 @default.
- W2023140356 cites W2039045540 @default.
- W2023140356 cites W2050059310 @default.
- W2023140356 cites W2084061676 @default.
- W2023140356 cites W2085618733 @default.
- W2023140356 cites W2117226405 @default.
- W2023140356 cites W2133676988 @default.
- W2023140356 doi "https://doi.org/10.1080/15287398409530544" @default.
- W2023140356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6492204" @default.
- W2023140356 hasPublicationYear "1984" @default.
- W2023140356 type Work @default.
- W2023140356 sameAs 2023140356 @default.
- W2023140356 citedByCount "14" @default.
- W2023140356 crossrefType "journal-article" @default.
- W2023140356 hasAuthorship W2023140356A5040725244 @default.
- W2023140356 hasAuthorship W2023140356A5053815447 @default.
- W2023140356 hasConcept C105702510 @default.
- W2023140356 hasConcept C126322002 @default.
- W2023140356 hasConcept C134018914 @default.
- W2023140356 hasConcept C178790620 @default.
- W2023140356 hasConcept C179253579 @default.
- W2023140356 hasConcept C185263204 @default.
- W2023140356 hasConcept C185592680 @default.
- W2023140356 hasConcept C2779133857 @default.
- W2023140356 hasConcept C2779491297 @default.
- W2023140356 hasConcept C2780358027 @default.
- W2023140356 hasConcept C2780923182 @default.
- W2023140356 hasConcept C2781149210 @default.
- W2023140356 hasConcept C29730261 @default.
- W2023140356 hasConcept C4141045 @default.
- W2023140356 hasConcept C42219234 @default.
- W2023140356 hasConcept C46762472 @default.
- W2023140356 hasConcept C537181965 @default.
- W2023140356 hasConcept C71924100 @default.
- W2023140356 hasConceptScore W2023140356C105702510 @default.
- W2023140356 hasConceptScore W2023140356C126322002 @default.
- W2023140356 hasConceptScore W2023140356C134018914 @default.
- W2023140356 hasConceptScore W2023140356C178790620 @default.
- W2023140356 hasConceptScore W2023140356C179253579 @default.
- W2023140356 hasConceptScore W2023140356C185263204 @default.
- W2023140356 hasConceptScore W2023140356C185592680 @default.
- W2023140356 hasConceptScore W2023140356C2779133857 @default.
- W2023140356 hasConceptScore W2023140356C2779491297 @default.
- W2023140356 hasConceptScore W2023140356C2780358027 @default.
- W2023140356 hasConceptScore W2023140356C2780923182 @default.
- W2023140356 hasConceptScore W2023140356C2781149210 @default.
- W2023140356 hasConceptScore W2023140356C29730261 @default.
- W2023140356 hasConceptScore W2023140356C4141045 @default.
- W2023140356 hasConceptScore W2023140356C42219234 @default.
- W2023140356 hasConceptScore W2023140356C46762472 @default.
- W2023140356 hasConceptScore W2023140356C537181965 @default.
- W2023140356 hasConceptScore W2023140356C71924100 @default.
- W2023140356 hasIssue "4-6" @default.
- W2023140356 hasLocation W20231403561 @default.
- W2023140356 hasLocation W20231403562 @default.
- W2023140356 hasOpenAccess W2023140356 @default.
- W2023140356 hasPrimaryLocation W20231403561 @default.
- W2023140356 hasRelatedWork W1488825183 @default.
- W2023140356 hasRelatedWork W1980295761 @default.
- W2023140356 hasRelatedWork W2000746949 @default.
- W2023140356 hasRelatedWork W2023140356 @default.
- W2023140356 hasRelatedWork W2058413748 @default.
- W2023140356 hasRelatedWork W2069586323 @default.
- W2023140356 hasRelatedWork W2091580561 @default.
- W2023140356 hasRelatedWork W2100592321 @default.
- W2023140356 hasRelatedWork W2748952813 @default.
- W2023140356 hasRelatedWork W2883787765 @default.
- W2023140356 hasVolume "13" @default.
- W2023140356 isParatext "false" @default.
- W2023140356 isRetracted "false" @default.
- W2023140356 magId "2023140356" @default.
- W2023140356 workType "article" @default.