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- W2023143549 abstract "Abstract During thymocyte differentiation, the T cell receptor (TCR)‐β genes are rearranged before the TCR‐α genes. Immature CD4 − 8 − double‐negative thymocytes with a productive rearrangement of the TCR‐β locus are selected to continue maturation to the CD4 + 8 + double‐positive stage, driven by signals through the pre‐TCR. The signals through the pre‐TCR can be synchronized by injection of mice with anti‐CD3ϵ monoclonal antibody. Using this approach, we demonstrated coordinated induction of a triad of responses in immature thymocytes: arrest of V to DJ rearrangement in the TCR‐β locus, transient down‐regulation of rearrangement‐activating gene (RAG)‐1 and RAG‐2 transcripts, and initiation of germ‐line transcription of the TCR‐α locus. These results suggest that the transition from TCR‐β to TCR‐α locus rearrangement is controlled by signal transduction through the pre‐TCR." @default.
- W2023143549 created "2016-06-24" @default.
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- W2023143549 date "1995-05-01" @default.
- W2023143549 modified "2023-10-01" @default.
- W2023143549 title "Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCR-α locus rearrangement in immature thymocytes by signaling through the CD3 complex" @default.
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- W2023143549 doi "https://doi.org/10.1002/eji.1830250519" @default.
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