Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023143765> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2023143765 endingPage "84S" @default.
- W2023143765 startingPage "83S" @default.
- W2023143765 abstract "Immature plaque neovessels contribute to atherosclerotic plaque instability and intraplaque hemorrhage by leaking erythrocytes and leukocytes in the plaque. Vascular endothelial growth factor receptor 2 (VEGFR2), together with the angiopoietin (Ang)-Tie2 system, regulates the maturation of growing neovessels. We have previously shown that murine vein graft lesions exhibit massive plaque neovascularization and that leaky vessels and intraplaque hemorrhage contribute to lesion growth. We hypothesized that inhibition of VEGFR2 results in more mature plaque microvessels and less intraplaque hemorrhage. Donor caval veins were engrafted in carotid arteries of recipient hypercholesterolemic ApoE3*Leiden mice (n = 14/group). Mice were treated at day 14, 17, 21 and 25 with VEGFR2 blocking antibodies (DC101) or control immunoglobulin G antibodies (10 mg/kg). At day 28, mice were euthanized for histologic analysis of the vein grafts. Morphometric analysis revealed a striking 50% decrease in vein graft segments that contain leaky vessels in the DC101-treated group. This was accompanied by a significant 25-fold decrease in extravasated erythrocytes. Furthermore, lesions that exhibit intraplaque hemorrhage showed a strong increase in both Ang-1 and Ang-2, indicative for immature neovessels. VEGFR2 blockade, however, did not affect the neovessel density in the lesions (control, 52 ± 19 neovessels/section; DC101, 63 ± 25 neovessels/section). Interestingly, the vein graft lesion area in the DC101 group was significantly reduced with 32% compared with the control group. Moreover, plaque stability was clearly increased in DC101-treated mice, determined by a 50% increase in collagen content and a 120% increase in SMC content. Blockade of VEGFR2 leads to reduced intraplaque hemorrhage, decreased vein graft lesion area, and increased plaque stability. This identifies plaque neovascularization as an attractive target for the treatment of unstable atherosclerotic diseases." @default.
- W2023143765 created "2016-06-24" @default.
- W2023143765 creator A5013152941 @default.
- W2023143765 creator A5015411763 @default.
- W2023143765 creator A5015970786 @default.
- W2023143765 creator A5029464045 @default.
- W2023143765 creator A5061036331 @default.
- W2023143765 creator A5063920107 @default.
- W2023143765 creator A5089698918 @default.
- W2023143765 date "2014-06-01" @default.
- W2023143765 modified "2023-10-15" @default.
- W2023143765 title "PS210. Inhibition of VEGFR2 Reduces Angiogenic Microvessel Leakiness in Murine Vein Graft Atherosclerotic Lesions and Increased Plaque Stability" @default.
- W2023143765 doi "https://doi.org/10.1016/j.jvs.2014.03.187" @default.
- W2023143765 hasPublicationYear "2014" @default.
- W2023143765 type Work @default.
- W2023143765 sameAs 2023143765 @default.
- W2023143765 citedByCount "0" @default.
- W2023143765 crossrefType "journal-article" @default.
- W2023143765 hasAuthorship W2023143765A5013152941 @default.
- W2023143765 hasAuthorship W2023143765A5015411763 @default.
- W2023143765 hasAuthorship W2023143765A5015970786 @default.
- W2023143765 hasAuthorship W2023143765A5029464045 @default.
- W2023143765 hasAuthorship W2023143765A5061036331 @default.
- W2023143765 hasAuthorship W2023143765A5063920107 @default.
- W2023143765 hasAuthorship W2023143765A5089698918 @default.
- W2023143765 hasBestOaLocation W20231437651 @default.
- W2023143765 hasConcept C126322002 @default.
- W2023143765 hasConcept C142724271 @default.
- W2023143765 hasConcept C159654299 @default.
- W2023143765 hasConcept C170493617 @default.
- W2023143765 hasConcept C203014093 @default.
- W2023143765 hasConcept C204232928 @default.
- W2023143765 hasConcept C2776436680 @default.
- W2023143765 hasConcept C2778271429 @default.
- W2023143765 hasConcept C2778468042 @default.
- W2023143765 hasConcept C2780394083 @default.
- W2023143765 hasConcept C2781156865 @default.
- W2023143765 hasConcept C502942594 @default.
- W2023143765 hasConcept C71924100 @default.
- W2023143765 hasConceptScore W2023143765C126322002 @default.
- W2023143765 hasConceptScore W2023143765C142724271 @default.
- W2023143765 hasConceptScore W2023143765C159654299 @default.
- W2023143765 hasConceptScore W2023143765C170493617 @default.
- W2023143765 hasConceptScore W2023143765C203014093 @default.
- W2023143765 hasConceptScore W2023143765C204232928 @default.
- W2023143765 hasConceptScore W2023143765C2776436680 @default.
- W2023143765 hasConceptScore W2023143765C2778271429 @default.
- W2023143765 hasConceptScore W2023143765C2778468042 @default.
- W2023143765 hasConceptScore W2023143765C2780394083 @default.
- W2023143765 hasConceptScore W2023143765C2781156865 @default.
- W2023143765 hasConceptScore W2023143765C502942594 @default.
- W2023143765 hasConceptScore W2023143765C71924100 @default.
- W2023143765 hasIssue "6" @default.
- W2023143765 hasLocation W20231437651 @default.
- W2023143765 hasOpenAccess W2023143765 @default.
- W2023143765 hasPrimaryLocation W20231437651 @default.
- W2023143765 hasRelatedWork W1975688002 @default.
- W2023143765 hasRelatedWork W2023173977 @default.
- W2023143765 hasRelatedWork W2033614003 @default.
- W2023143765 hasRelatedWork W2038730217 @default.
- W2023143765 hasRelatedWork W2078757264 @default.
- W2023143765 hasRelatedWork W2275670663 @default.
- W2023143765 hasRelatedWork W2375525337 @default.
- W2023143765 hasRelatedWork W2402143932 @default.
- W2023143765 hasRelatedWork W3137522520 @default.
- W2023143765 hasRelatedWork W4247317957 @default.
- W2023143765 hasVolume "59" @default.
- W2023143765 isParatext "false" @default.
- W2023143765 isRetracted "false" @default.
- W2023143765 magId "2023143765" @default.
- W2023143765 workType "article" @default.