FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023144798> ?p ?o ?g. }

• W2023144798 abstract "Objective: Coexistent Type Two Diabetes Mellitus (TTDM) and hypertension exposes patients to severe co-morbidities. Complex polypharmacy suggested by international organizations leads to the increased pill burden and decreased patient compliance which leads to worsening of conditions. Materials and Methods: Present research aims at the formulation and development of fixed dose combination (FDC) for treatment of coexistent hypertension and TTDM as it will help in increasing patient compliance. Literature survey and patient survey facilitated the selection of metformin HCl, telmisartan, atorvastatin and aspirin for the formulation of FDC. Formulation and development of enteric coated aspirin tablet and the bilayer tablet of metformin HCl, telmisartan & atorvastatin calcium were two major parts of this research.Aspirin was enteric coated by compression coating technique to avoid gastric irritation. Bilayer tablet separating metformin HCl layer from the layer of a mixture of telmisartan and atorvastatin calcium was prepared to avoid the physical incompatibility problem between metformin HCl and telmisartan.The final FDC formulation was prepared by encapsulating, enteric coated aspirin tablet and bilayer tablet in a size 00 capsule and subjected to accelerated stability studies. Results: Batch F2 of bilayer tablet containing one layer of metformin HCl and the other layer having a mixture of telmisartan& atorvastatin calcium releases more than 80% of metformin HCl, telmisartan and atorvastatin calcium within 1 hour. Batch A2E of enteric coated aspirin tablet was found to show delayed and complete drug release as compared to A2D within 3.5 hours. Similarity factor f2 was found to be 69.33. After long term storage of formulation at 40 o C/75% RH, stability of drug components remained unaffected. Conclusion: FDC of antihypertensive and antidiabetic agent will be revolutionary in the treatment of coexistent TTDM and hypertension as it will be a cheaper alternative to" @default.
• W2023144798 created "2016-06-24" @default.
• W2023144798 creator A5021661810 @default.
• W2023144798 creator A5029517935 @default.
• W2023144798 creator A5038031331 @default.
• W2023144798 date "2014-12-16" @default.
• W2023144798 modified "2023-09-30" @default.
• W2023144798 title "Formulation and Development of Fixed Dose Combination of Antihypertensive and Antidiabetic Agent for treatment of Co-existent Type Two Diabetes Mellitus and Hypertension" @default.
• W2023144798 cites W1669146696 @default.
• W2023144798 cites W1981706606 @default.
• W2023144798 cites W1988164721 @default.
• W2023144798 cites W1994251194 @default.
• W2023144798 cites W2000768391 @default.
• W2023144798 cites W2011854637 @default.
• W2023144798 cites W2016622896 @default.
• W2023144798 cites W2042731281 @default.
• W2023144798 cites W2071874717 @default.
• W2023144798 cites W2085001426 @default.
• W2023144798 cites W2104962153 @default.
• W2023144798 cites W2109187758 @default.
• W2023144798 cites W2114498807 @default.
• W2023144798 cites W2126975151 @default.
• W2023144798 cites W2136225651 @default.
• W2023144798 cites W2138707864 @default.
• W2023144798 cites W2151295407 @default.
• W2023144798 cites W2156108549 @default.
• W2023144798 cites W2176800792 @default.
• W2023144798 cites W2183122785 @default.
• W2023144798 cites W2401235003 @default.
• W2023144798 cites W2510708214 @default.
• W2023144798 cites W2183810684 @default.
• W2023144798 doi "https://doi.org/10.5530/ijper.48.4s.15" @default.
• W2023144798 hasPublicationYear "2014" @default.
• W2023144798 type Work @default.
• W2023144798 sameAs 2023144798 @default.
• W2023144798 citedByCount "1" @default.
• W2023144798 countsByYear W20231447982016 @default.
• W2023144798 crossrefType "journal-article" @default.
• W2023144798 hasAuthorship W2023144798A5021661810 @default.
• W2023144798 hasAuthorship W2023144798A5029517935 @default.
• W2023144798 hasAuthorship W2023144798A5038031331 @default.
• W2023144798 hasBestOaLocation W20231447981 @default.
• W2023144798 hasConcept C126322002 @default.
• W2023144798 hasConcept C134018914 @default.
• W2023144798 hasConcept C2777482532 @default.
• W2023144798 hasConcept C2777628954 @default.
• W2023144798 hasConcept C2779716603 @default.
• W2023144798 hasConcept C2780323712 @default.
• W2023144798 hasConcept C2909500757 @default.
• W2023144798 hasConcept C2910068830 @default.
• W2023144798 hasConcept C555293320 @default.
• W2023144798 hasConcept C71924100 @default.
• W2023144798 hasConcept C84393581 @default.
• W2023144798 hasConcept C98274493 @default.
• W2023144798 hasConceptScore W2023144798C126322002 @default.
• W2023144798 hasConceptScore W2023144798C134018914 @default.
• W2023144798 hasConceptScore W2023144798C2777482532 @default.
• W2023144798 hasConceptScore W2023144798C2777628954 @default.
• W2023144798 hasConceptScore W2023144798C2779716603 @default.
• W2023144798 hasConceptScore W2023144798C2780323712 @default.
• W2023144798 hasConceptScore W2023144798C2909500757 @default.
• W2023144798 hasConceptScore W2023144798C2910068830 @default.
• W2023144798 hasConceptScore W2023144798C555293320 @default.
• W2023144798 hasConceptScore W2023144798C71924100 @default.
• W2023144798 hasConceptScore W2023144798C84393581 @default.
• W2023144798 hasConceptScore W2023144798C98274493 @default.
• W2023144798 hasLocation W20231447981 @default.
• W2023144798 hasOpenAccess W2023144798 @default.
• W2023144798 hasPrimaryLocation W20231447981 @default.
• W2023144798 hasRelatedWork W2648939454 @default.
• W2023144798 hasRelatedWork W1565662824 @default.
• W2023144798 hasRelatedWork W2343294604 @default.
• W2023144798 hasRelatedWork W2775810502 @default.
• W2023144798 hasRelatedWork W2782768254 @default.
• W2023144798 hasRelatedWork W2816227956 @default.
• W2023144798 hasRelatedWork W2841914909 @default.
• W2023144798 hasRelatedWork W2849214354 @default.
• W2023144798 hasRelatedWork W2849446741 @default.
• W2023144798 hasRelatedWork W2860524949 @default.
• W2023144798 hasRelatedWork W2924388006 @default.
• W2023144798 hasRelatedWork W2926063133 @default.
• W2023144798 hasRelatedWork W2929604111 @default.
• W2023144798 hasRelatedWork W2932438242 @default.
• W2023144798 hasRelatedWork W2933764629 @default.
• W2023144798 hasRelatedWork W2998644774 @default.
• W2023144798 hasRelatedWork W3039404504 @default.
• W2023144798 hasRelatedWork W3140539535 @default.
• W2023144798 hasRelatedWork W3144157744 @default.
• W2023144798 hasRelatedWork W3169647401 @default.
• W2023144798 isParatext "false" @default.
• W2023144798 isRetracted "false" @default.
• W2023144798 magId "2023144798" @default.
• W2023144798 workType "article" @default.