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- W2023146519 abstract "To the Editor.— The recent article by Ralph I. Horwitz, MD, and Alvan R. Feinstein, MD, Improved Observational Method for Studying Therapeutic Efficacy (1981;246:2455), and accompanying editorials (1981;246:2481, 2482) imply that selection of cases and controls from within what was originally set up as a closed cohort is a novel and innovative epidemiologic method. This may be true for clinical trials, but case-control studies within cohorts are not unusual in epidemiologic research on industrial populations. 1,2 The cohort from which Drs Horwitz and Feinstein selected both cases and controls was described as part of a large observational study of patients hospitalized with myocardial infarction. Industrial cohorts usually consist of employees in a manufacturing facility. 3 Drs Horwitz and Feinstein used lidocaine therapy as the independent variable for calculating odds ratios. Their dependent variable was death. In industrial case-control studies, the independent variable may be exposure to a chemical or a" @default.
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- W2023146519 date "1982-04-16" @default.
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- W2023146519 title "Alternative Strategies to Randomized Clinical Trials" @default.
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- W2023146519 doi "https://doi.org/10.1001/jama.1982.03320400020023" @default.
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