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• W2023146545 abstract "Tissue damage results in a variety of molecular signals that activate elements of the immune system. Recent years have seen a growing awareness that key regulators of these events are extracellular nucleotides that signal through purinergic receptors. Haematophagous insects and ticks secrete enzymes in their saliva that degrade nucleotides, thus inhibiting haemostasis and minimizing the ensuing pain and inflammatory reactions provoked by these mediators. The discovery of an enzymatic cascade of nucleotide-metabolizing enzymes in secreted products of Trichinella spiralis suggests that endoparasites use similar mechanisms to modulate host purinergic signalling. Tissue damage results in a variety of molecular signals that activate elements of the immune system. Recent years have seen a growing awareness that key regulators of these events are extracellular nucleotides that signal through purinergic receptors. Haematophagous insects and ticks secrete enzymes in their saliva that degrade nucleotides, thus inhibiting haemostasis and minimizing the ensuing pain and inflammatory reactions provoked by these mediators. The discovery of an enzymatic cascade of nucleotide-metabolizing enzymes in secreted products of Trichinella spiralis suggests that endoparasites use similar mechanisms to modulate host purinergic signalling." @default.
• W2023146545 created "2016-06-24" @default.
• W2023146545 creator A5029260456 @default.
• W2023146545 creator A5058611051 @default.
• W2023146545 date "2005-01-01" @default.
• W2023146545 modified "2023-09-23" @default.
• W2023146545 title "Parasite nucleotide-metabolizing enzymes and host purinergic signalling" @default.
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• W2023146545 doi "https://doi.org/10.1016/j.pt.2004.10.005" @default.
• W2023146545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15639736" @default.
• W2023146545 hasPublicationYear "2005" @default.
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