FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023146805> ?p ?o ?g. }

• W2023146805 endingPage "10682" @default.
• W2023146805 startingPage "10670" @default.
• W2023146805 abstract "Nuclear export of incompletely spliced RNAs is a prerequisite for retroviral replication. Complex retroviruses like human immunodeficiency virus (HIV) encode a viral transport factor (Rev), which binds to its target sequence on the RNA genome and directs it into the Crm-1-mediated export pathway. Other retroviruses, like Mason-Pfizer monkey virus, contain cis-acting constitutive RNA transport elements (CTE) which achieve nuclear export of intron-containing RNA via cellular transport factors. Here, we describe the identification and characterization of a novel cis-acting orientation-dependent RNA expression element in the coding region of the murine intracisternal A-type particle (IAP) MIA14. This IAP expression element (IAPE) can functionally replace the Rev system in the expression of HIV-1 Gag proteins but functions independently of Crm-1. The presence of this element is needed for the expression of the IAP Gag proteins, indicating its biological significance. The IAPE can be functionally replaced by placing a CTE on the MIA14 RNA, further supporting its role in mRNA export. Northern blot analysis revealed that total RNA, as well as cytoplasmic RNA, was increased when the element was present. The element was mapped to a predicted stem-loop structure in the 3' part of the pol open reading frame. There was no overall homology between the IAPE and the CTE, but there was complete sequence identity between short putative single-stranded loops. Deletion of these loops from the IAPE severely reduced Rev-independent Gag expression." @default.
• W2023146805 created "2016-06-24" @default.
• W2023146805 creator A5009783412 @default.
• W2023146805 creator A5036005209 @default.
• W2023146805 creator A5038844784 @default.
• W2023146805 creator A5054481265 @default.
• W2023146805 creator A5073234868 @default.
• W2023146805 date "2001-11-15" @default.
• W2023146805 modified "2023-10-16" @default.
• W2023146805 title "A New RNA Element Located in the Coding Region of a Murine Endogenous Retrovirus Can Functionally Replace the Rev/Rev-Responsive Element System in Human Immunodeficiency Virus Type 1 Gag Expression" @default.
• W2023146805 cites W107231475 @default.
• W2023146805 cites W1510096565 @default.
• W2023146805 cites W1530482967 @default.
• W2023146805 cites W1533176189 @default.
• W2023146805 cites W1538258690 @default.
• W2023146805 cites W1562998360 @default.
• W2023146805 cites W1596124800 @default.
• W2023146805 cites W1769569140 @default.
• W2023146805 cites W1792619367 @default.
• W2023146805 cites W1798684498 @default.
• W2023146805 cites W1843147791 @default.
• W2023146805 cites W1857373397 @default.
• W2023146805 cites W1867411047 @default.
• W2023146805 cites W1909505938 @default.
• W2023146805 cites W1963143659 @default.
• W2023146805 cites W1963705823 @default.
• W2023146805 cites W1964916693 @default.
• W2023146805 cites W1964997986 @default.
• W2023146805 cites W1967680682 @default.
• W2023146805 cites W1970846933 @default.
• W2023146805 cites W1979585903 @default.
• W2023146805 cites W1981457569 @default.
• W2023146805 cites W1987008065 @default.
• W2023146805 cites W1995403172 @default.
• W2023146805 cites W2002804296 @default.
• W2023146805 cites W2006301581 @default.
• W2023146805 cites W2008922773 @default.
• W2023146805 cites W2015087800 @default.
• W2023146805 cites W2021023197 @default.
• W2023146805 cites W2021397335 @default.
• W2023146805 cites W2023250124 @default.
• W2023146805 cites W2028972497 @default.
• W2023146805 cites W2037094815 @default.
• W2023146805 cites W20371925 @default.
• W2023146805 cites W2037534409 @default.
• W2023146805 cites W2040516035 @default.
• W2023146805 cites W2042170550 @default.
• W2023146805 cites W2045298333 @default.
• W2023146805 cites W2069490539 @default.
• W2023146805 cites W2080366675 @default.
• W2023146805 cites W2084486123 @default.
• W2023146805 cites W2091103467 @default.
• W2023146805 cites W2091856409 @default.
• W2023146805 cites W2104554283 @default.
• W2023146805 cites W2111500868 @default.
• W2023146805 cites W2112001822 @default.
• W2023146805 cites W2116711309 @default.
• W2023146805 cites W2117951174 @default.
• W2023146805 cites W2120463956 @default.
• W2023146805 cites W2122245694 @default.
• W2023146805 cites W2126238684 @default.
• W2023146805 cites W2138725935 @default.
• W2023146805 cites W2146527174 @default.
• W2023146805 cites W2151298994 @default.
• W2023146805 cites W2156414211 @default.
• W2023146805 cites W2159391740 @default.
• W2023146805 cites W2163828429 @default.
• W2023146805 cites W2164302365 @default.
• W2023146805 cites W2165226718 @default.
• W2023146805 cites W2170629529 @default.
• W2023146805 cites W2171171901 @default.
• W2023146805 cites W2171258458 @default.
• W2023146805 cites W2171305498 @default.
• W2023146805 cites W2185323554 @default.
• W2023146805 cites W2217492872 @default.
• W2023146805 cites W4249680089 @default.
• W2023146805 cites W4251106005 @default.
• W2023146805 doi "https://doi.org/10.1128/jvi.75.22.10670-10682.2001" @default.
• W2023146805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114649" @default.
• W2023146805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11602709" @default.
• W2023146805 hasPublicationYear "2001" @default.
• W2023146805 type Work @default.
• W2023146805 sameAs 2023146805 @default.
• W2023146805 citedByCount "37" @default.
• W2023146805 countsByYear W20231468052012 @default.
• W2023146805 countsByYear W20231468052014 @default.
• W2023146805 countsByYear W20231468052015 @default.
• W2023146805 countsByYear W20231468052016 @default.
• W2023146805 countsByYear W20231468052017 @default.
• W2023146805 countsByYear W20231468052018 @default.
• W2023146805 countsByYear W20231468052019 @default.
• W2023146805 countsByYear W20231468052021 @default.
• W2023146805 crossrefType "journal-article" @default.
• W2023146805 hasAuthorship W2023146805A5009783412 @default.
• W2023146805 hasAuthorship W2023146805A5036005209 @default.
• W2023146805 hasAuthorship W2023146805A5038844784 @default.
• W2023146805 hasAuthorship W2023146805A5054481265 @default.
• W2023146805 hasAuthorship W2023146805A5073234868 @default.

• next