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- W2023147549 abstract "We compared the ability of spantide I and II to antagonize tachykinins in monoreceptor bioassays. Both peptides antagonized the response to substance P methylester in the guinea-pig ileum (NK-1 receptor-mediated) with greater affinity than the responses mediated by NK-2 or NK-3 receptors in other bioassays. Spantide II was about 10 times more potent than spantide I as an NK-1 antagonist and also possessed some selectivity for the NK-2 receptor subtype present in the hamster trachea. Spantide II is a suitable tool to assess the role of NK-1 receptors in the central and peripheral nervous system." @default.
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- W2023147549 date "1991-06-01" @default.
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- W2023147549 title "Activity of spantide I and II at various tachykinin receptors and NK-2 tachykinin receptor subtypes" @default.
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- W2023147549 doi "https://doi.org/10.1016/0014-2999(91)90648-a" @default.
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