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- W2023149552 abstract "The bacitracin resistance of Bacillus licheniformis, a producer of bacitracin, is mediated by the ABC transporter Bcr. Bacillus subtilis cells carrying bcr genes on high-copy number plasmids developed collateral detergent sensitivity, as did human cells with overexpressed multidrug resistance P-glycoprotein. Resistance against bacitracin and sensitivity of resistant cells to detergents were shown to be inseparable phenomena associated with the membrane part of Bcr transporter, namely protein BcrC. A fused protein, consisting of ATP-binding protein BcrA and membrane component BcrC was constructed. It resembled a half molecule of P-glycoprotein and was capable of providing a significant degree of antibiotic resistance and detergent sensitivity." @default.
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- W2023149552 date "2000-07-01" @default.
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- W2023149552 title "The role of the bacitracin ABC transporter in bacitracin resistance and collateral detergent sensitivity" @default.
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- W2023149552 doi "https://doi.org/10.1111/j.1574-6968.2000.tb09176.x" @default.
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