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- W2023149623 endingPage "819" @default.
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- W2023149623 abstract "The effects on cell proliferation of arylhydrocarbon receptor (AhR) agonists in estrogen-responsive T47D and ZR-75-1 cells were investigated. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the non-ortho-substituted polychlorinated biphenyl (PCB) congeners, PCB 77, PCB 81, PCB 126, and PCB 169 each inhibited 17β-estradiol (E2)-stimulated cell proliferation in a dose–responsive manner. In the absence of added E2, TCDD, PCB 77, PCB 81, and PCB 169 had no significant effect on cell proliferation, while PCB 126 at high concentrations caused slight elevations. The order of effective inhibition of E2-stimulated cell proliferation by the PCB congeners was: PCB 81>PCB 126≃PCB 169>PCB 77. In the comparative literature, mammalian TEFs for these congeners toxic potency are in the order: PCB 126>PCB 169>PCB 81≃PCB 77 [Organohalogen Compd. 34 (1997) 237]. Our results thus show an unexpected different pattern for the inhibitory effects of PCBs congeners on E2-mediated cell proliferation." @default.
- W2023149623 created "2016-06-24" @default.
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- W2023149623 date "2004-12-01" @default.
- W2023149623 modified "2023-10-15" @default.
- W2023149623 title "TCDD and PCBs inhibit breast cancer cell proliferation in vitro" @default.
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- W2023149623 doi "https://doi.org/10.1016/j.tiv.2004.04.004" @default.
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