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• W2023149837 abstract "Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in terms of antimycobacterial activity. Interestingly, cells of resistant genotype secreted more nitric oxide, TNF-alpha and IL-12, but less IL-6, than susceptible cells, when stimulated with IFN-gamma alone or in combination with lipopolysaccharide. Nevertheless, no significant differences were observed between the two cell lines in terms of IL-1 beta or IL-10 secretion, or on assessment of cytokine production following exposure to a massive dose of lipopolysaccharide. Overall, these data provide the first evidence that resistant/susceptible genotype influences antimycobacterial activity, NO and cytokine production in microglial cells, the prototype of cerebral macrophages." @default.
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• W2023149837 date "1999-11-01" @default.
• W2023149837 modified "2023-09-27" @default.
• W2023149837 title "Differential effector and secretory functions of microglial cell lines derived from BCG-resistant and -susceptible congenic mouse strains" @default.
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• W2023149837 doi "https://doi.org/10.1016/s0165-5728(99)00127-7" @default.
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