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• W2023151401 abstract "Background Disturbances in central serotonin function have been implicated in impulsive and aggressive behavior. A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression. The serotonin transporter (5-HTT) is the primary action site for selective serotonin reuptake inhibitors (SSRIs). Several studies of major depression have shown that the l allele of 5-HTTLPR is associated with better SSRI antidepressant effects than the s allele. Methods This study investigates the association between response of impulsivity to treatment with fluoxetine and 5-HTTLPR polymorphism in 49 personality disordered patients. Additionally, we studied TPH1, 5HT1B and 5HT2C receptor polymorphisms as predictors of response in this population. Results Results reveal that patients with the l/l genotype of 5-HTTLPR had a significantly better response to fluoxetine when compared to s allele carriers, as evaluated on the basis of total (P<0.05) and Aggression subscale (P<0.01) Overt Aggression Scale Modified-score percentage change. There were no significant associations between fluoxetine response and TPH1 (A218C) (−6525 A>G) (−5806 G>T), HTR1B (G861C) and HTR2C (G68C) genotype groups. Conclusion This is the first study assessing the association between these polymorphisms and anti-impulsive response to fluoxetine in personality disorder. As the s genotype is associated with a poorer selective serotonin reuptake inhibitors response in major depression, bulimia nervosa and borderline personality disorder, it could represent a common biological background for SSRI response." @default.
• W2023151401 created "2016-06-24" @default.
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• W2023151401 date "2010-02-01" @default.
• W2023151401 modified "2023-10-03" @default.
• W2023151401 title "Fluoxetine response in impulsive–aggressive behavior and serotonin transporter polymorphism in personality disorder" @default.
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• W2023151401 doi "https://doi.org/10.1097/ypg.0b013e328335125d" @default.
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