FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023152830> ?p ?o ?g. }

• W2023152830 endingPage "230" @default.
• W2023152830 startingPage "222" @default.
• W2023152830 abstract "Fluoroquinolone antiinfective drugs exhibit phototoxic, photogenotoxic, and photocarcinogenic activities in experimental systems which may be interrelated. Clinafloxacin (CLX), a new fluoroquinolone, is a potent antiinfective agent being developed for use in life-threatening infections. While this drug has previously been demonstrated to be phototoxic, this report evaluated the photogenotoxic and photocarcinogenic potential of CLX. When Skh-1 mice were administered CLX in the presence of ultraviolet light (UVA) at the maximum tolerated dose expected for a photocarcinogenicity bioassay, induction of DNA strand breakage was noted in keratinocytes isolated from these animals. When compared with other well-studied fluoroquinolones in vitro, CLX and Lomefloxacin (LMX) were equally effective in producing chromosome damage and DNA strand breakage in Chinese hamster ovary (CHO) cells exposed to UVA. Treatment of CHO cells with CLX in the presence of UVA also resulted in hydroxyl radical formation. However, coincubation of CHO cells with CLX and various antioxidants markedly reduced hydroxyl radical formation, but inhibited photogenotoxicity only to a limited extent. Thus, while reactive oxygen species contribute to the photogenotoxic activity of CLX, other factors may be involved. Since CLX exhibits both phototoxic and photogenotoxic activity, we predict that CLX would be photocarcinogenic in vivo. The present study suggests that under conditions of human exposure, the potential risk for CLX-induced photocarcinogenicity is small." @default.
• W2023152830 created "2016-06-24" @default.
• W2023152830 creator A5012913780 @default.
• W2023152830 creator A5028392784 @default.
• W2023152830 creator A5046253765 @default.
• W2023152830 creator A5055315264 @default.
• W2023152830 date "1999-05-01" @default.
• W2023152830 modified "2023-10-16" @default.
• W2023152830 title "In VitroPhotogenotoxic Activity of Clinafloxacin: A Paradigm Predicting Photocarcinogenicity" @default.
• W2023152830 cites W1825467595 @default.
• W2023152830 cites W1928045734 @default.
• W2023152830 cites W1950516314 @default.
• W2023152830 cites W1968035468 @default.
• W2023152830 cites W1968059313 @default.
• W2023152830 cites W1973194258 @default.
• W2023152830 cites W1978955132 @default.
• W2023152830 cites W1983079792 @default.
• W2023152830 cites W1989369977 @default.
• W2023152830 cites W2001229080 @default.
• W2023152830 cites W2023245693 @default.
• W2023152830 cites W2024840579 @default.
• W2023152830 cites W2027193063 @default.
• W2023152830 cites W2038836093 @default.
• W2023152830 cites W2056077906 @default.
• W2023152830 cites W2056168322 @default.
• W2023152830 cites W2092629964 @default.
• W2023152830 cites W2099650842 @default.
• W2023152830 cites W2100583984 @default.
• W2023152830 cites W2108492771 @default.
• W2023152830 cites W2121411057 @default.
• W2023152830 cites W2122548705 @default.
• W2023152830 cites W2137121725 @default.
• W2023152830 cites W2143790856 @default.
• W2023152830 cites W2151128886 @default.
• W2023152830 cites W2327717525 @default.
• W2023152830 cites W4231872672 @default.
• W2023152830 doi "https://doi.org/10.1006/taap.1999.8653" @default.
• W2023152830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10222314" @default.
• W2023152830 hasPublicationYear "1999" @default.
• W2023152830 type Work @default.
• W2023152830 sameAs 2023152830 @default.
• W2023152830 citedByCount "44" @default.
• W2023152830 countsByYear W20231528302012 @default.
• W2023152830 countsByYear W20231528302013 @default.
• W2023152830 countsByYear W20231528302014 @default.
• W2023152830 countsByYear W20231528302015 @default.
• W2023152830 countsByYear W20231528302016 @default.
• W2023152830 countsByYear W20231528302018 @default.
• W2023152830 countsByYear W20231528302019 @default.
• W2023152830 crossrefType "journal-article" @default.
• W2023152830 hasAuthorship W2023152830A5012913780 @default.
• W2023152830 hasAuthorship W2023152830A5028392784 @default.
• W2023152830 hasAuthorship W2023152830A5046253765 @default.
• W2023152830 hasAuthorship W2023152830A5055315264 @default.
• W2023152830 hasConcept C143425029 @default.
• W2023152830 hasConcept C153911025 @default.
• W2023152830 hasConcept C170493617 @default.
• W2023152830 hasConcept C175656101 @default.
• W2023152830 hasConcept C185592680 @default.
• W2023152830 hasConcept C202751555 @default.
• W2023152830 hasConcept C20639190 @default.
• W2023152830 hasConcept C2778512257 @default.
• W2023152830 hasConcept C2778575167 @default.
• W2023152830 hasConcept C2778746504 @default.
• W2023152830 hasConcept C2778923102 @default.
• W2023152830 hasConcept C501593827 @default.
• W2023152830 hasConcept C552990157 @default.
• W2023152830 hasConcept C55493867 @default.
• W2023152830 hasConcept C86803240 @default.
• W2023152830 hasConcept C89423630 @default.
• W2023152830 hasConcept C98274493 @default.
• W2023152830 hasConceptScore W2023152830C143425029 @default.
• W2023152830 hasConceptScore W2023152830C153911025 @default.
• W2023152830 hasConceptScore W2023152830C170493617 @default.
• W2023152830 hasConceptScore W2023152830C175656101 @default.
• W2023152830 hasConceptScore W2023152830C185592680 @default.
• W2023152830 hasConceptScore W2023152830C202751555 @default.
• W2023152830 hasConceptScore W2023152830C20639190 @default.
• W2023152830 hasConceptScore W2023152830C2778512257 @default.
• W2023152830 hasConceptScore W2023152830C2778575167 @default.
• W2023152830 hasConceptScore W2023152830C2778746504 @default.
• W2023152830 hasConceptScore W2023152830C2778923102 @default.
• W2023152830 hasConceptScore W2023152830C501593827 @default.
• W2023152830 hasConceptScore W2023152830C552990157 @default.
• W2023152830 hasConceptScore W2023152830C55493867 @default.
• W2023152830 hasConceptScore W2023152830C86803240 @default.
• W2023152830 hasConceptScore W2023152830C89423630 @default.
• W2023152830 hasConceptScore W2023152830C98274493 @default.
• W2023152830 hasIssue "3" @default.
• W2023152830 hasLocation W20231528301 @default.
• W2023152830 hasLocation W20231528302 @default.
• W2023152830 hasOpenAccess W2023152830 @default.
• W2023152830 hasPrimaryLocation W20231528301 @default.
• W2023152830 hasRelatedWork W1970469548 @default.
• W2023152830 hasRelatedWork W1982208097 @default.
• W2023152830 hasRelatedWork W2023152830 @default.
• W2023152830 hasRelatedWork W2024840579 @default.
• W2023152830 hasRelatedWork W2032580699 @default.

• next