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• W2023154401 abstract "Phytochemical investigation of an ethyl-acetate extract of the stem bark of Markhamia tomentosa (Bignoniaceae), which had good antimalarial activity in vitro, resulted in the isolation of eight known compounds: 2-acetylnaphtho[2,3-b]furan-4,9-dione (1), 2-acetyl-6-methoxynaphtho[2,3-b]furan-4,9-dione (2), oleanolic acid (3), pomolic acid (4), 3-acetylpomolic acid (5), tormentic acid (6), β-sitosterol (7) and β-sitosterol-3-O-β-D-glucopyranoside (8). The structures of these compounds were established by spectroscopic methods. Each of compounds 1, 2, 4 and 5 was evaluated in vitro for its antiprotozoal activities against the ring stages of two chloroquine-resistant strains of Plasmodium falciparum (K1 and W2), the amastigotes of Leishmania donovani, and the bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited potent antiprotozoal activities, they also showed high toxicity against a mammalian (L-6) cell line." @default.
• W2023154401 created "2016-06-24" @default.
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• W2023154401 date "2010-07-01" @default.
• W2023154401 modified "2023-10-17" @default.
• W2023154401 title "Antiprotozoal activities of some constituents of<i>Markhamia</i><i>tomentosa</i>(Bignoniaceae)" @default.
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• W2023154401 doi "https://doi.org/10.1179/136485910x12743554760180" @default.
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