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- W2023154792 abstract "To examine the effects of intravesical suramin on N-methyl-N-nitrosurea (MNU)-induced bladder tumors in Fischer 344 rats.Multiple cohorts of female rats received four biweekly intravesical instillations of MNU. A control group received no other treatment, the experimental group received 25 mg/kg intravesical suramin twice a week beginning at week 6.After 18 weeks from the first instillation of MNU, 60% to 65% of control animals developed papillary transitional cell carcinoma, compared with only 0% to 10% of the suramin-treated animals (P = 0.01 to P = 0.0007). There was no local or systemic toxicity observed.Intravesical suramin is an effective chemopreventative therapy for transitional cell carcinoma in vivo with minimal toxicity." @default.
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- W2023154792 date "1995-01-01" @default.
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- W2023154792 title "Intravesical suramin in the prevention of transitional cell carcinoma" @default.
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- W2023154792 doi "https://doi.org/10.1016/s0090-4295(95)96720-6" @default.
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