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- W2023155619 abstract "Aquatic hypoxia is a seasonal condition in some coastal and continental wetlands where co-exposure with polycyclic aromatic hydrocarbons (PAHs) pollution may be detrimental to the biota. In the present study, adult tilapia, an euryoxic fish of high economic importance, were intraperitoneally injected with benzo[a]pyrene (BaP) (20 mg kg(-1)) and then exposed to graded hypoxia to assess combined effects on some detoxification and fitness parameters. Seventy-two hours after a stepped decrease in dissolved oxygen (<2 mg L(-1)), BaP treatment resulted in a significant diminution on the biliary BaP concentration (70% of normoxic group) and an increase in blood glucose levels (2.17-fold compared with normoxic group). These effects returned to control values in the following 48 h of hypoxia exposure. BaP-induced CYP1A mRNA levels were unaffected by hypoxia, suggesting that reduced bile BaP concentration may be related with effects on protein amount or enzyme activities. LDH mRNA levels, blood lactate and hematocrit remained without change, suggesting no extreme detrimental effects for tilapia in the short-term of the BaP-hypoxia challenge. Our results indicate that BaP treatment and hypoxia targeted glucose metabolism and biliary BaP elimination, probably by favoring the storage of BaP in tilapia tissues." @default.
- W2023155619 created "2016-06-24" @default.
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- W2023155619 date "2013-06-01" @default.
- W2023155619 modified "2023-09-23" @default.
- W2023155619 title "Bile benzo[a]pyrene concentration and hepatic CYP1A induction in hypoxic adult tilapia (Oreochromis niloticus)" @default.
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- W2023155619 doi "https://doi.org/10.1016/j.chemosphere.2013.03.034" @default.
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