FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023156098> ?p ?o ?g. }

• W2023156098 endingPage "3503" @default.
• W2023156098 startingPage "3499" @default.
• W2023156098 abstract "4-Methylpyrazole, in a dose producing inhibition of alcohol dehydrogenase (alcohol:NAD + oxidoreductase, EC 1.1.1.1), was given alone or together with ethanol (10%) as sole drinking fluid to growing rats for up to 38 weeks. Their weight curves remained normal. Electron microscopy of liver, kidney, and heart revealed no changes related to treatment. Hematologic analysis showed normal values for blood and bone marrow. Several clinical chemical parameters showed no impairment of liver or kidney function, except for an enhancement of the microsomal drug-metabolizing activity after concurrent administration of 4-methylpyrazole and ethanol. A study on rats receiving 4-methylpyrazole and ethanol indicated a mutual interaction of the two compounds or the metabolites, leading to increased concentration in the blood of the compounds and reduced formation of 4-hydroxymethylpyrazole, the primary metabolite of 4-methylpyrazole. In monkeys, elimination of 4-methylpyrazole followed a linear course. 4-Hydroxymethylpyrazole accumulated to a level of at most 10% of that of 4-methylpyrazole. Concurrent administration of methanol inhibited the elimination of 4-methylpyrazole about 25%, and 4-methylpyrazole produced a profound inhibition of the oxidation of methanol. 4-Methylpyrazole, at a level in the plasma of more than 10 μM, prevented accumulation of the toxic metabolite formic acid in methanol-poisoned monkeys, and repeated injections of 4-methylpyrazole abolished methanol toxicity in monkeys receiving lethal doses of methanol. The present investigation indicates that 4-methylpyrazole, with its low toxicity and strong inhibition of alcohol oxidation, is a valuable tool for experimental studies of alcohol metabolism and its effects. It illustrates the usefulness of the monkey as a model to study 4-methylpyrazole activity and toxicity in light of its possible use for treating methanol poisoning in human beings." @default.
• W2023156098 created "2016-06-24" @default.
• W2023156098 creator A5011054233 @default.
• W2023156098 creator A5025024613 @default.
• W2023156098 creator A5034750292 @default.
• W2023156098 creator A5037855244 @default.
• W2023156098 creator A5058709074 @default.
• W2023156098 creator A5083688723 @default.
• W2023156098 date "1979-07-01" @default.
• W2023156098 modified "2023-10-18" @default.
• W2023156098 title "Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: An approach to therapy against methanol poisoning" @default.
• W2023156098 cites W1900373396 @default.
• W2023156098 cites W1964094498 @default.
• W2023156098 cites W1964888552 @default.
• W2023156098 cites W1965153101 @default.
• W2023156098 cites W1967660304 @default.
• W2023156098 cites W1972344615 @default.
• W2023156098 cites W1983280582 @default.
• W2023156098 cites W1997714496 @default.
• W2023156098 cites W2007118676 @default.
• W2023156098 cites W2012694008 @default.
• W2023156098 cites W2016346366 @default.
• W2023156098 cites W2020133093 @default.
• W2023156098 cites W2022905021 @default.
• W2023156098 cites W2029407499 @default.
• W2023156098 cites W2069643752 @default.
• W2023156098 cites W2076183022 @default.
• W2023156098 cites W2082513483 @default.
• W2023156098 cites W2083950980 @default.
• W2023156098 cites W2086474904 @default.
• W2023156098 cites W2087074693 @default.
• W2023156098 cites W2089768612 @default.
• W2023156098 cites W2090306342 @default.
• W2023156098 cites W2408879729 @default.
• W2023156098 cites W2415816478 @default.
• W2023156098 cites W2417693306 @default.
• W2023156098 cites W2421382240 @default.
• W2023156098 cites W2435472205 @default.
• W2023156098 cites W2472461560 @default.
• W2023156098 cites W41156754 @default.
• W2023156098 cites W90648369 @default.
• W2023156098 doi "https://doi.org/10.1073/pnas.76.7.3499" @default.
• W2023156098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/383854" @default.
• W2023156098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/115004" @default.
• W2023156098 hasPublicationYear "1979" @default.
• W2023156098 type Work @default.
• W2023156098 sameAs 2023156098 @default.
• W2023156098 citedByCount "58" @default.
• W2023156098 countsByYear W20231560982015 @default.
• W2023156098 countsByYear W20231560982017 @default.
• W2023156098 countsByYear W20231560982018 @default.
• W2023156098 countsByYear W20231560982021 @default.
• W2023156098 countsByYear W20231560982022 @default.
• W2023156098 crossrefType "journal-article" @default.
• W2023156098 hasAuthorship W2023156098A5011054233 @default.
• W2023156098 hasAuthorship W2023156098A5025024613 @default.
• W2023156098 hasAuthorship W2023156098A5034750292 @default.
• W2023156098 hasAuthorship W2023156098A5037855244 @default.
• W2023156098 hasAuthorship W2023156098A5058709074 @default.
• W2023156098 hasAuthorship W2023156098A5083688723 @default.
• W2023156098 hasBestOaLocation W20231560981 @default.
• W2023156098 hasConcept C116263406 @default.
• W2023156098 hasConcept C126322002 @default.
• W2023156098 hasConcept C178790620 @default.
• W2023156098 hasConcept C185592680 @default.
• W2023156098 hasConcept C2777344606 @default.
• W2023156098 hasConcept C2777477808 @default.
• W2023156098 hasConcept C2779607525 @default.
• W2023156098 hasConcept C2780091579 @default.
• W2023156098 hasConcept C2780161600 @default.
• W2023156098 hasConcept C2781066024 @default.
• W2023156098 hasConcept C2909879501 @default.
• W2023156098 hasConcept C29730261 @default.
• W2023156098 hasConcept C55493867 @default.
• W2023156098 hasConcept C71924100 @default.
• W2023156098 hasConcept C98274493 @default.
• W2023156098 hasConceptScore W2023156098C116263406 @default.
• W2023156098 hasConceptScore W2023156098C126322002 @default.
• W2023156098 hasConceptScore W2023156098C178790620 @default.
• W2023156098 hasConceptScore W2023156098C185592680 @default.
• W2023156098 hasConceptScore W2023156098C2777344606 @default.
• W2023156098 hasConceptScore W2023156098C2777477808 @default.
• W2023156098 hasConceptScore W2023156098C2779607525 @default.
• W2023156098 hasConceptScore W2023156098C2780091579 @default.
• W2023156098 hasConceptScore W2023156098C2780161600 @default.
• W2023156098 hasConceptScore W2023156098C2781066024 @default.
• W2023156098 hasConceptScore W2023156098C2909879501 @default.
• W2023156098 hasConceptScore W2023156098C29730261 @default.
• W2023156098 hasConceptScore W2023156098C55493867 @default.
• W2023156098 hasConceptScore W2023156098C71924100 @default.
• W2023156098 hasConceptScore W2023156098C98274493 @default.
• W2023156098 hasIssue "7" @default.
• W2023156098 hasLocation W20231560981 @default.
• W2023156098 hasLocation W20231560982 @default.
• W2023156098 hasLocation W20231560983 @default.
• W2023156098 hasLocation W20231560984 @default.
• W2023156098 hasOpenAccess W2023156098 @default.
• W2023156098 hasPrimaryLocation W20231560981 @default.

• next