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• W2023156380 abstract "Intrinsically disordered proteins (IDPs) are predicted to represent a significant fraction of the human genome, and the development of meaningful molecular descriptions of these proteins remains a key challenge for contemporary structural biology. In order to describe the conformational behavior of IDPs, a molecular representation of the disordered state based on diverse sources of structural data that often exhibit complex and very different averaging behavior is required. In this study, we propose a combination of paramagnetic relaxation enhancements (PREs) and residual dipolar couplings (RDCs) to define both long-range and local structural features of IDPs in solution. We demonstrate that ASTEROIDS, an ensemble selection algorithm, faithfully reproduces intramolecular contacts, even in the presence of highly diffuse, ill-defined target interactions. We also show that explicit modeling of spin-label mobility significantly improves the reproduction of experimental PRE data, even in the case of highly disordered proteins. Prediction of the effects of transient long-range contacts on RDC profiles reveals that weak intramolecular interactions can induce a severe distortion of the profiles that compromises the description of local conformational sampling if it is not correctly taken into account. We have developed a solution to this problem that involves efficiently combining RDC and PRE data to simultaneously determine long-range and local structure in highly flexible proteins. This combined analysis is shown to be essential for the accurate interpretation of experimental data from α-synuclein, an important IDP involved in human neurodegenerative disease, confirming the presence of long-range order between distant regions in the protein." @default.
• W2023156380 created "2016-06-24" @default.
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• W2023156380 date "2010-05-25" @default.
• W2023156380 modified "2023-10-16" @default.
• W2023156380 title "NMR Characterization of Long-Range Order in Intrinsically Disordered Proteins" @default.
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• W2023156380 cites W1974124630 @default.
• W2023156380 cites W1974929259 @default.
• W2023156380 cites W1975311020 @default.
• W2023156380 cites W1976470237 @default.
• W2023156380 cites W1978313975 @default.
• W2023156380 cites W1980856759 @default.
• W2023156380 cites W1982383324 @default.
• W2023156380 cites W1988624456 @default.
• W2023156380 cites W1989847819 @default.
• W2023156380 cites W1992022732 @default.
• W2023156380 cites W1996274823 @default.
• W2023156380 cites W1998177378 @default.
• W2023156380 cites W2001621989 @default.
• W2023156380 cites W2002864274 @default.
• W2023156380 cites W2002900623 @default.
• W2023156380 cites W2003365738 @default.
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• W2023156380 cites W2006199861 @default.
• W2023156380 cites W2006422372 @default.
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• W2023156380 cites W2020209643 @default.
• W2023156380 cites W2022175833 @default.
• W2023156380 cites W2023245921 @default.
• W2023156380 cites W2029925798 @default.
• W2023156380 cites W2030499668 @default.
• W2023156380 cites W2033782813 @default.
• W2023156380 cites W2034299708 @default.
• W2023156380 cites W2036062965 @default.
• W2023156380 cites W2044730187 @default.
• W2023156380 cites W2048072382 @default.
• W2023156380 cites W2049587523 @default.
• W2023156380 cites W2052606462 @default.
• W2023156380 cites W2052660967 @default.
• W2023156380 cites W2053278954 @default.
• W2023156380 cites W2057688439 @default.
• W2023156380 cites W2057835619 @default.
• W2023156380 cites W2058238447 @default.
• W2023156380 cites W2060745831 @default.
• W2023156380 cites W2062557777 @default.
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• W2023156380 cites W2069053167 @default.
• W2023156380 cites W2069226687 @default.
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• W2023156380 cites W2085852844 @default.
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• W2023156380 doi "https://doi.org/10.1021/ja101645g" @default.
• W2023156380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20499903" @default.
• W2023156380 hasPublicationYear "2010" @default.
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