Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023158097> ?p ?o ?g. }
- W2023158097 endingPage "3602" @default.
- W2023158097 startingPage "3588" @default.
- W2023158097 abstract "Conformational diseases are associated with the conversion of normal proteins into aggregation-prone toxic conformers with structures similar to that of β-amyloid. Spatial distribution of amyloid-like proteins into intracellular quality control centers can be beneficial, but cellular mechanisms for protective aggregation remain unclear. We used a high-copy suppressor screen in yeast to identify roles for the Hsp70 system in spatial organization of toxic polyglutamine-expanded Huntingtin (Huntingtin with 103Q glutamine stretch [Htt103Q]) into benign assemblies. Under toxic conditions, Htt103Q accumulates in unassembled states and speckled cytosolic foci. Subtle modulation of Sti1 activity reciprocally affects Htt toxicity and the packaging of Htt103Q into foci. Loss of Sti1 exacerbates Htt toxicity and hinders foci formation, whereas elevation of Sti1 suppresses Htt toxicity while organizing small Htt103Q foci into larger assemblies. Sti1 also suppresses cytotoxicity of the glutamine-rich yeast prion [RNQ+] while reorganizing speckled Rnq1–monomeric red fluorescent protein into distinct foci. Sti1-inducible foci are perinuclear and contain proteins that are bound by the amyloid indicator dye thioflavin-T. Sti1 is an Hsp70 cochaperone that regulates the spatial organization of amyloid-like proteins in the cytosol and thereby buffers proteotoxicity caused by amyloid-like proteins." @default.
- W2023158097 created "2016-06-24" @default.
- W2023158097 creator A5030361320 @default.
- W2023158097 creator A5031413734 @default.
- W2023158097 creator A5035058978 @default.
- W2023158097 creator A5064289613 @default.
- W2023158097 date "2013-12-01" @default.
- W2023158097 modified "2023-09-27" @default.
- W2023158097 title "The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins" @default.
- W2023158097 cites W1520171546 @default.
- W2023158097 cites W1558079148 @default.
- W2023158097 cites W1872122 @default.
- W2023158097 cites W1902219868 @default.
- W2023158097 cites W1955276614 @default.
- W2023158097 cites W1965060663 @default.
- W2023158097 cites W1966923623 @default.
- W2023158097 cites W1967025628 @default.
- W2023158097 cites W1970950417 @default.
- W2023158097 cites W1980825524 @default.
- W2023158097 cites W1986906983 @default.
- W2023158097 cites W1990839192 @default.
- W2023158097 cites W2000204824 @default.
- W2023158097 cites W2002634381 @default.
- W2023158097 cites W2004543547 @default.
- W2023158097 cites W2006905408 @default.
- W2023158097 cites W2009568691 @default.
- W2023158097 cites W2013110945 @default.
- W2023158097 cites W2013429682 @default.
- W2023158097 cites W2019618662 @default.
- W2023158097 cites W2023111823 @default.
- W2023158097 cites W2033532530 @default.
- W2023158097 cites W2037250030 @default.
- W2023158097 cites W2039411295 @default.
- W2023158097 cites W2043676526 @default.
- W2023158097 cites W2043693325 @default.
- W2023158097 cites W2044448989 @default.
- W2023158097 cites W2044996749 @default.
- W2023158097 cites W2052049724 @default.
- W2023158097 cites W2052816884 @default.
- W2023158097 cites W2054218114 @default.
- W2023158097 cites W2054485625 @default.
- W2023158097 cites W2055655674 @default.
- W2023158097 cites W2056009047 @default.
- W2023158097 cites W2058236814 @default.
- W2023158097 cites W2058546459 @default.
- W2023158097 cites W2058993984 @default.
- W2023158097 cites W2059406989 @default.
- W2023158097 cites W2064700750 @default.
- W2023158097 cites W2069448508 @default.
- W2023158097 cites W2072744250 @default.
- W2023158097 cites W2073665574 @default.
- W2023158097 cites W2077250786 @default.
- W2023158097 cites W2078662153 @default.
- W2023158097 cites W2080887297 @default.
- W2023158097 cites W2083907721 @default.
- W2023158097 cites W2084414517 @default.
- W2023158097 cites W2094992100 @default.
- W2023158097 cites W2097772334 @default.
- W2023158097 cites W2098076627 @default.
- W2023158097 cites W2103736543 @default.
- W2023158097 cites W2104615400 @default.
- W2023158097 cites W2109502717 @default.
- W2023158097 cites W2112335210 @default.
- W2023158097 cites W2116769005 @default.
- W2023158097 cites W2121753059 @default.
- W2023158097 cites W2130399516 @default.
- W2023158097 cites W2131926693 @default.
- W2023158097 cites W2132404134 @default.
- W2023158097 cites W2134802476 @default.
- W2023158097 cites W2140937615 @default.
- W2023158097 cites W2144741305 @default.
- W2023158097 cites W2148176855 @default.
- W2023158097 cites W2148505202 @default.
- W2023158097 cites W2149761960 @default.
- W2023158097 cites W2149996174 @default.
- W2023158097 cites W2151325719 @default.
- W2023158097 cites W2165186407 @default.
- W2023158097 cites W2167613565 @default.
- W2023158097 cites W2171417214 @default.
- W2023158097 cites W2171885622 @default.
- W2023158097 cites W4240929891 @default.
- W2023158097 doi "https://doi.org/10.1091/mbc.e13-06-0315" @default.
- W2023158097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842988" @default.
- W2023158097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24109600" @default.
- W2023158097 hasPublicationYear "2013" @default.
- W2023158097 type Work @default.
- W2023158097 sameAs 2023158097 @default.
- W2023158097 citedByCount "60" @default.
- W2023158097 countsByYear W20231580972014 @default.
- W2023158097 countsByYear W20231580972015 @default.
- W2023158097 countsByYear W20231580972016 @default.
- W2023158097 countsByYear W20231580972017 @default.
- W2023158097 countsByYear W20231580972018 @default.
- W2023158097 countsByYear W20231580972019 @default.
- W2023158097 countsByYear W20231580972020 @default.
- W2023158097 countsByYear W20231580972021 @default.
- W2023158097 countsByYear W20231580972022 @default.
- W2023158097 crossrefType "journal-article" @default.