FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023158162> ?p ?o ?g. }

• W2023158162 endingPage "239" @default.
• W2023158162 startingPage "234" @default.
• W2023158162 abstract "Abstract Background and Aim: Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease and a definite carcinogen for gastric adenocarcinoma. However, the underlying pathogenic mechanisms are not fully understood. Interleukin‐1 (IL‐1) is a key cytokine involved in H. pylori ‐induced gastric inflammation. The present study aimed to determine polymorphisms of IL‐1B and IL‐1 receptor antagonist ( IL‐1RN ) genes and their association with H. pylori infection and gastroduodenal diseases in Chinese patients. Methods: Three hundred and ninety‐nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non‐cardiac gastric cancer) and 264 healthy controls were genotyped for IL‐1B‐ 511 and IL‐1RN gene polymorphisms by the PCR‐RFLP method. H. pylori infection status was determined by a validated serological test. Results: The frequency of IL‐1B‐ 511 T allele was significantly higher in H. pylori positive patients with non‐cardiac gastric cancer than in both H. pylori negative patients with non‐cardiac gastric cancer (60% vs 46%, P = 0.0342, OR = 1.666, 95% confidence interval [CI]: 1.045–2.656) and in healthy controls (60% vs 48%, P = 0.0071, OR = 1.665, 95%CI: 1.149–2.412). However, the polymorphism was not associated with chronic gastritis and duodenal ulcer. Multivariate logistic regression analyses identified that IL‐1B‐ 511 T/T carrier status was an independent risk factor for non‐cardiac gastric cancer in the presence of H. pylori infection (adjusted OR = 3.01, 95%CI: 1.27–7.11, P = 0.01), and the frequency of IL‐1B‐ 511 T allele was an increased risk factor for developing gastric cancer ( P = 0.03, adjusted OR = 2.29, 95%CI: 1.08–4.86). There was no association between IL‐1RN gene polymorphisms and H. pylori infection and other gastroduodenal diseases. Conclusion: IL‐1B‐ 511 T allele is associated with H. pylori infection in non‐cardiac gastric cancer in a Chinese population. The IL‐1B‐ 511 gene polymorphism appears to play an important role in gastric carcinogenesis in Chinese patients with H. pylori infection." @default.
• W2023158162 created "2016-06-24" @default.
• W2023158162 creator A5020075019 @default.
• W2023158162 creator A5027331800 @default.
• W2023158162 creator A5031811109 @default.
• W2023158162 creator A5037829735 @default.
• W2023158162 creator A5052819986 @default.
• W2023158162 creator A5070120817 @default.
• W2023158162 creator A5070699088 @default.
• W2023158162 creator A5077945540 @default.
• W2023158162 creator A5089329488 @default.
• W2023158162 date "2007-01-29" @default.
• W2023158162 modified "2023-10-18" @default.
• W2023158162 title "Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population" @default.
• W2023158162 cites W1515994079 @default.
• W2023158162 cites W1574330564 @default.
• W2023158162 cites W1965341361 @default.
• W2023158162 cites W1972831584 @default.
• W2023158162 cites W1980717001 @default.
• W2023158162 cites W1985331862 @default.
• W2023158162 cites W1987399881 @default.
• W2023158162 cites W1992945893 @default.
• W2023158162 cites W2009107334 @default.
• W2023158162 cites W2025710239 @default.
• W2023158162 cites W2026860891 @default.
• W2023158162 cites W2040541004 @default.
• W2023158162 cites W2049468108 @default.
• W2023158162 cites W2051464579 @default.
• W2023158162 cites W2058676866 @default.
• W2023158162 cites W2060391362 @default.
• W2023158162 cites W2066353321 @default.
• W2023158162 cites W2069378448 @default.
• W2023158162 cites W2073977304 @default.
• W2023158162 cites W2074966969 @default.
• W2023158162 cites W2084036096 @default.
• W2023158162 cites W2091164526 @default.
• W2023158162 cites W2106396979 @default.
• W2023158162 cites W2145962148 @default.
• W2023158162 cites W2159449545 @default.
• W2023158162 cites W2166547001 @default.
• W2023158162 cites W2168248222 @default.
• W2023158162 cites W4244839516 @default.
• W2023158162 doi "https://doi.org/10.1111/j.1440-1746.2006.04379.x" @default.
• W2023158162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17295877" @default.
• W2023158162 hasPublicationYear "2007" @default.
• W2023158162 type Work @default.
• W2023158162 sameAs 2023158162 @default.
• W2023158162 citedByCount "49" @default.
• W2023158162 countsByYear W20231581622012 @default.
• W2023158162 countsByYear W20231581622013 @default.
• W2023158162 countsByYear W20231581622014 @default.
• W2023158162 countsByYear W20231581622015 @default.
• W2023158162 countsByYear W20231581622016 @default.
• W2023158162 countsByYear W20231581622017 @default.
• W2023158162 countsByYear W20231581622018 @default.
• W2023158162 countsByYear W20231581622019 @default.
• W2023158162 countsByYear W20231581622021 @default.
• W2023158162 countsByYear W20231581622023 @default.
• W2023158162 crossrefType "journal-article" @default.
• W2023158162 hasAuthorship W2023158162A5020075019 @default.
• W2023158162 hasAuthorship W2023158162A5027331800 @default.
• W2023158162 hasAuthorship W2023158162A5031811109 @default.
• W2023158162 hasAuthorship W2023158162A5037829735 @default.
• W2023158162 hasAuthorship W2023158162A5052819986 @default.
• W2023158162 hasAuthorship W2023158162A5070120817 @default.
• W2023158162 hasAuthorship W2023158162A5070699088 @default.
• W2023158162 hasAuthorship W2023158162A5077945540 @default.
• W2023158162 hasAuthorship W2023158162A5089329488 @default.
• W2023158162 hasConcept C121608353 @default.
• W2023158162 hasConcept C126322002 @default.
• W2023158162 hasConcept C2776409635 @default.
• W2023158162 hasConcept C2778677798 @default.
• W2023158162 hasConcept C2780561475 @default.
• W2023158162 hasConcept C71924100 @default.
• W2023158162 hasConcept C90924648 @default.
• W2023158162 hasConceptScore W2023158162C121608353 @default.
• W2023158162 hasConceptScore W2023158162C126322002 @default.
• W2023158162 hasConceptScore W2023158162C2776409635 @default.
• W2023158162 hasConceptScore W2023158162C2778677798 @default.
• W2023158162 hasConceptScore W2023158162C2780561475 @default.
• W2023158162 hasConceptScore W2023158162C71924100 @default.
• W2023158162 hasConceptScore W2023158162C90924648 @default.
• W2023158162 hasIssue "2" @default.
• W2023158162 hasLocation W20231581621 @default.
• W2023158162 hasLocation W20231581622 @default.
• W2023158162 hasOpenAccess W2023158162 @default.
• W2023158162 hasPrimaryLocation W20231581621 @default.
• W2023158162 hasRelatedWork W1868503177 @default.
• W2023158162 hasRelatedWork W2029946886 @default.
• W2023158162 hasRelatedWork W2072110481 @default.
• W2023158162 hasRelatedWork W2125587655 @default.
• W2023158162 hasRelatedWork W2207516306 @default.
• W2023158162 hasRelatedWork W2287302929 @default.
• W2023158162 hasRelatedWork W2393372398 @default.
• W2023158162 hasRelatedWork W2418070587 @default.
• W2023158162 hasRelatedWork W2982204045 @default.
• W2023158162 hasRelatedWork W3211622953 @default.
• W2023158162 hasVolume "22" @default.

• next