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- W2023159558 abstract "Developing artificial scaffolding structures in vitro in order to mimic physiological-relevant situations in vivo is critical in many biological and medical arenas including bone and cartilage generation, biomaterials, small-scale biomedical devices, tissue engineering, as well as the development of nanofabrication methods. We focus on using simple physical principles (photolithography) and chemical techniques (liquid vapor deposition) to build non-cytotoxic scaffolds with a nanometer resolution through using silicon substrates as the backbone. This method merges an optics-based approach with chemical restructuring to modify the surface properties of an IC-compatible material, switching from hydrophilicity to hydrophobicity. Through this nanofabrication-based approach that we developed, hydrophobic oxidized silicon nanosponges were obtained. We then probed cellular responses—examining cytoskeletal and morphological changes in living cells through a combination of fluorescence microscopy and scanning electron microscopy—via culturing Chinese hamster ovary cells, HIG-82 fibroblasts and Madin–Darby canine kidney cells on these silicon nanosponges. This study has demonstrated the potential applications of using these silicon-based nanopatterns such as influencing cellular behaviors at desired locations with a micro-/nanometer level." @default.
- W2023159558 created "2016-06-24" @default.
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- W2023159558 date "2012-07-01" @default.
- W2023159558 modified "2023-10-18" @default.
- W2023159558 title "Micropatterning of mammalian cells on inorganic-based nanosponges" @default.
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- W2023159558 doi "https://doi.org/10.1016/j.biomaterials.2012.03.071" @default.
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