FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023160229> ?p ?o ?g. }

• W2023160229 endingPage "2423" @default.
• W2023160229 startingPage "2414" @default.
• W2023160229 abstract "Notopterygium forbesii Boiss (NF) has been used as a traditional Chinese medicine for the treatment of common cold and rheumatism. However, there has been limited research on the biological properties of NF, and the mechanisms of action remain unknown. Here, we aimed to study the mechanism of NF-induced heme oxygenase-1 (HO-1) in human fetal hepatocytes (HFHs) and to identify the constituents responsible. Exposure of HFHs to NF causes oxidative stress with the accumulation of reactive species, which in turn leads to the phosphorylation of p38 MAPK and nuclear accumulation of Nrf2 transcription factor, and eventually increased levels of HO-1 mRNA and protein. The increases in reactive species and HO-1 protein are inhibited by agonists of glucocorticoid receptors (GR), such as RU28362, prednisolone, and dexamethasone, as well as by N-acetyl-L-cysteine and SB203580 (a p38 inhibitor), suggesting a role of GR in NF-induced increases in reactive species and HO-1. Assay-guided fractionation of NF led to three active compounds, phenethyl ferulate, bergaptol, and isoimperatorin, that were found to increase oxidative stress and HO-1 protein levels in HFHs. The induction of HO-1 protein in response to moderate oxidative stress may explain some of the beneficial pharmacological effects of NF." @default.
• W2023160229 created "2016-06-24" @default.
• W2023160229 creator A5006872949 @default.
• W2023160229 creator A5047168734 @default.
• W2023160229 creator A5053726981 @default.
• W2023160229 creator A5071314271 @default.
• W2023160229 date "2008-11-04" @default.
• W2023160229 modified "2023-09-23" @default.
• W2023160229 title "<i>Notopterygium forbesii</i> Boiss Extract and Its Active Constituents Increase Reactive Species and Heme Oxygenase-1 in Human Fetal Hepatocytes: Mechanisms of Action" @default.
• W2023160229 cites W1525800139 @default.
• W2023160229 cites W1924592317 @default.
• W2023160229 cites W1966516130 @default.
• W2023160229 cites W1968906540 @default.
• W2023160229 cites W1975024270 @default.
• W2023160229 cites W1977913875 @default.
• W2023160229 cites W1987857240 @default.
• W2023160229 cites W1995633773 @default.
• W2023160229 cites W1995726976 @default.
• W2023160229 cites W1996826558 @default.
• W2023160229 cites W2001019228 @default.
• W2023160229 cites W2006252682 @default.
• W2023160229 cites W2006794523 @default.
• W2023160229 cites W2008963388 @default.
• W2023160229 cites W2010469776 @default.
• W2023160229 cites W2016366656 @default.
• W2023160229 cites W2016587256 @default.
• W2023160229 cites W2018264979 @default.
• W2023160229 cites W2025286289 @default.
• W2023160229 cites W2038333453 @default.
• W2023160229 cites W2043661250 @default.
• W2023160229 cites W2044217881 @default.
• W2023160229 cites W2050044704 @default.
• W2023160229 cites W2052548231 @default.
• W2023160229 cites W2060662813 @default.
• W2023160229 cites W2076152331 @default.
• W2023160229 cites W2080221988 @default.
• W2023160229 cites W2083721229 @default.
• W2023160229 cites W2083882252 @default.
• W2023160229 cites W2087412890 @default.
• W2023160229 cites W2088936315 @default.
• W2023160229 cites W2089097264 @default.
• W2023160229 cites W2097732899 @default.
• W2023160229 cites W2100898826 @default.
• W2023160229 cites W2124122523 @default.
• W2023160229 cites W2127822816 @default.
• W2023160229 cites W2169161738 @default.
• W2023160229 cites W2225224752 @default.
• W2023160229 cites W2325740861 @default.
• W2023160229 doi "https://doi.org/10.1021/tx800301f" @default.
• W2023160229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19548360" @default.
• W2023160229 hasPublicationYear "2008" @default.
• W2023160229 type Work @default.
• W2023160229 sameAs 2023160229 @default.
• W2023160229 citedByCount "14" @default.
• W2023160229 countsByYear W20231602292012 @default.
• W2023160229 countsByYear W20231602292013 @default.
• W2023160229 countsByYear W20231602292014 @default.
• W2023160229 countsByYear W20231602292016 @default.
• W2023160229 countsByYear W20231602292017 @default.
• W2023160229 countsByYear W20231602292019 @default.
• W2023160229 countsByYear W20231602292020 @default.
• W2023160229 crossrefType "journal-article" @default.
• W2023160229 hasAuthorship W2023160229A5006872949 @default.
• W2023160229 hasAuthorship W2023160229A5047168734 @default.
• W2023160229 hasAuthorship W2023160229A5053726981 @default.
• W2023160229 hasAuthorship W2023160229A5071314271 @default.
• W2023160229 hasConcept C104317684 @default.
• W2023160229 hasConcept C170493617 @default.
• W2023160229 hasConcept C181199279 @default.
• W2023160229 hasConcept C185592680 @default.
• W2023160229 hasConcept C2776151105 @default.
• W2023160229 hasConcept C2776217839 @default.
• W2023160229 hasConcept C2778004101 @default.
• W2023160229 hasConcept C2779219270 @default.
• W2023160229 hasConcept C48349386 @default.
• W2023160229 hasConcept C51551487 @default.
• W2023160229 hasConcept C55493867 @default.
• W2023160229 hasConcept C57074206 @default.
• W2023160229 hasConcept C59493245 @default.
• W2023160229 hasConcept C62478195 @default.
• W2023160229 hasConcept C86339819 @default.
• W2023160229 hasConcept C86803240 @default.
• W2023160229 hasConcept C98270193 @default.
• W2023160229 hasConcept C98274493 @default.
• W2023160229 hasConceptScore W2023160229C104317684 @default.
• W2023160229 hasConceptScore W2023160229C170493617 @default.
• W2023160229 hasConceptScore W2023160229C181199279 @default.
• W2023160229 hasConceptScore W2023160229C185592680 @default.
• W2023160229 hasConceptScore W2023160229C2776151105 @default.
• W2023160229 hasConceptScore W2023160229C2776217839 @default.
• W2023160229 hasConceptScore W2023160229C2778004101 @default.
• W2023160229 hasConceptScore W2023160229C2779219270 @default.
• W2023160229 hasConceptScore W2023160229C48349386 @default.
• W2023160229 hasConceptScore W2023160229C51551487 @default.
• W2023160229 hasConceptScore W2023160229C55493867 @default.
• W2023160229 hasConceptScore W2023160229C57074206 @default.
• W2023160229 hasConceptScore W2023160229C59493245 @default.
• W2023160229 hasConceptScore W2023160229C62478195 @default.

• next