FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023160419> ?p ?o ?g. }

• W2023160419 endingPage "47" @default.
• W2023160419 startingPage "38" @default.
• W2023160419 abstract "Infections with influenza A viruses still pose a major threat to humans and several animal species. The occurrence of highly pathogenic avian influenza viruses of the H5N1 subtype capable to infect and kill humans highlights the urgent need for new and efficient countermeasures against this viral disease. Here we demonstrate that a polyphenol rich extract (CYSTUS052) from the Mediterranean plant Cistus incanus exerts a potent anti-influenza virus activity in A549 or MDCK cell cultures infected with prototype avian and human influenza strains of different subtypes. CYSTUS052 treatment resulted in a reduction of progeny virus titers of up to two logs. At the effective dose of 50 μg/ml the extract did not exhibit apparent harming effects on cell viability, metabolism or proliferation, which is consistent with the fact that these plant extracts are already used in traditional medicine in southern Europe for centuries without any reported complications. Viruses did not develop resistance to CYSTUS052 when compared to amantadine that resulted in the generation of resistant variants after only a few passages. On a molecular basis the protective effect of CYSTUS052 appears to be mainly due to binding of the polymeric polyphenol components of the extract to the virus surface, thereby inhibiting binding of the hemagglutinin to cellular receptors. Thus, a local application of CYSTUS052 at the viral entry routes may be a promising approach that may help to protect from influenza virus infections." @default.
• W2023160419 created "2016-06-24" @default.
• W2023160419 creator A5007763095 @default.
• W2023160419 creator A5016200442 @default.
• W2023160419 creator A5019933869 @default.
• W2023160419 creator A5040011003 @default.
• W2023160419 creator A5040409972 @default.
• W2023160419 creator A5058408501 @default.
• W2023160419 creator A5064902858 @default.
• W2023160419 creator A5072520222 @default.
• W2023160419 creator A5084579146 @default.
• W2023160419 creator A5089788791 @default.
• W2023160419 date "2007-10-01" @default.
• W2023160419 modified "2023-10-01" @default.
• W2023160419 title "A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance" @default.
• W2023160419 cites W1559903407 @default.
• W2023160419 cites W1576782716 @default.
• W2023160419 cites W168938078 @default.
• W2023160419 cites W177909858 @default.
• W2023160419 cites W1851303894 @default.
• W2023160419 cites W1914622032 @default.
• W2023160419 cites W1974735376 @default.
• W2023160419 cites W1976414727 @default.
• W2023160419 cites W1978863022 @default.
• W2023160419 cites W1984148285 @default.
• W2023160419 cites W1988851601 @default.
• W2023160419 cites W1998902451 @default.
• W2023160419 cites W1999542797 @default.
• W2023160419 cites W2001465291 @default.
• W2023160419 cites W2003782931 @default.
• W2023160419 cites W2011006965 @default.
• W2023160419 cites W2041862222 @default.
• W2023160419 cites W2048219637 @default.
• W2023160419 cites W2053334597 @default.
• W2023160419 cites W2054436951 @default.
• W2023160419 cites W2055886928 @default.
• W2023160419 cites W2057457924 @default.
• W2023160419 cites W2076787553 @default.
• W2023160419 cites W2080979357 @default.
• W2023160419 cites W2094199486 @default.
• W2023160419 cites W2114004260 @default.
• W2023160419 cites W2117200691 @default.
• W2023160419 cites W2117982433 @default.
• W2023160419 cites W2118453378 @default.
• W2023160419 cites W2135041346 @default.
• W2023160419 cites W2140230248 @default.
• W2023160419 cites W2149087734 @default.
• W2023160419 cites W2150892779 @default.
• W2023160419 cites W2153531642 @default.
• W2023160419 cites W2155734592 @default.
• W2023160419 cites W2157177671 @default.
• W2023160419 cites W2158523178 @default.
• W2023160419 cites W2160881014 @default.
• W2023160419 cites W2161034194 @default.
• W2023160419 cites W2171580171 @default.
• W2023160419 cites W2186303827 @default.
• W2023160419 cites W2399117155 @default.
• W2023160419 cites W2402027689 @default.
• W2023160419 cites W2408198815 @default.
• W2023160419 cites W2586781288 @default.
• W2023160419 doi "https://doi.org/10.1016/j.antiviral.2007.05.002" @default.
• W2023160419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17572513" @default.
• W2023160419 hasPublicationYear "2007" @default.
• W2023160419 type Work @default.
• W2023160419 sameAs 2023160419 @default.
• W2023160419 citedByCount "131" @default.
• W2023160419 countsByYear W20231604192012 @default.
• W2023160419 countsByYear W20231604192013 @default.
• W2023160419 countsByYear W20231604192014 @default.
• W2023160419 countsByYear W20231604192015 @default.
• W2023160419 countsByYear W20231604192016 @default.
• W2023160419 countsByYear W20231604192017 @default.
• W2023160419 countsByYear W20231604192018 @default.
• W2023160419 countsByYear W20231604192019 @default.
• W2023160419 countsByYear W20231604192020 @default.
• W2023160419 countsByYear W20231604192021 @default.
• W2023160419 countsByYear W20231604192022 @default.
• W2023160419 countsByYear W20231604192023 @default.
• W2023160419 crossrefType "journal-article" @default.
• W2023160419 hasAuthorship W2023160419A5007763095 @default.
• W2023160419 hasAuthorship W2023160419A5016200442 @default.
• W2023160419 hasAuthorship W2023160419A5019933869 @default.
• W2023160419 hasAuthorship W2023160419A5040011003 @default.
• W2023160419 hasAuthorship W2023160419A5040409972 @default.
• W2023160419 hasAuthorship W2023160419A5058408501 @default.
• W2023160419 hasAuthorship W2023160419A5064902858 @default.
• W2023160419 hasAuthorship W2023160419A5072520222 @default.
• W2023160419 hasAuthorship W2023160419A5084579146 @default.
• W2023160419 hasAuthorship W2023160419A5089788791 @default.
• W2023160419 hasConcept C140704245 @default.
• W2023160419 hasConcept C159047783 @default.
• W2023160419 hasConcept C2522874641 @default.
• W2023160419 hasConcept C2777546802 @default.
• W2023160419 hasConcept C2778004101 @default.
• W2023160419 hasConcept C2778692840 @default.
• W2023160419 hasConcept C519248777 @default.
• W2023160419 hasConcept C55493867 @default.
• W2023160419 hasConcept C58475186 @default.

• next