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- W2023161008 abstract "Invasion of human immunodeficiency virus (HIV) into the central and peripheral nervous system produces a wide range of neurological symptoms, which continue to persist even with adequate therapeutic suppression of the systemic viremia. The development of therapies designed to prevent the neurological complications of HIV require a detailed understanding of the mechanisms of virus penetration into the nervous system, infection, and subsequent neuropathogenesis. These processes, however, are difficult to study in humans. The identification of animal lentiviruses similar to HIV has provided useful models of HIV infection that have greatly facilitated these efforts. This review summarizes contributions made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system. In vivo studies on FIV have provided insights into the natural progression of CNS disease as well as the contribution of various risk factors. In vitro studies have contributed to our understanding of immune cell trafficking, CNS infection and neuropathogenesis. Together, these studies have made unique contributions to our understanding of (1) lentiviral interactions at the blood-cerebrospinal fluid (CSF) barrier within the choroid plexus, (2) early FIV invasion and pathogenesis in the brain, and (3) lentiviral effects on intracellular calcium deregulation and neuronal dysfunction. The ability to combine in vitro and in vivo studies on FIV offers enormous potential to explore neuropathogenic mechanisms and generate information necessary for the development of effective therapeutic interventions." @default.
- W2023161008 created "2016-06-24" @default.
- W2023161008 creator A5023078550 @default.
- W2023161008 date "2006-11-28" @default.
- W2023161008 modified "2023-10-13" @default.
- W2023161008 title "Feline Immunodeficiency Virus Neuropathogenesis: From Cats to Calcium" @default.
- W2023161008 cites W1481355729 @default.
- W2023161008 cites W1497358716 @default.
- W2023161008 cites W1531920376 @default.
- W2023161008 cites W1539868110 @default.
- W2023161008 cites W1571153387 @default.
- W2023161008 cites W1581091695 @default.
- W2023161008 cites W1639407471 @default.
- W2023161008 cites W1683411584 @default.
- W2023161008 cites W1690665404 @default.
- W2023161008 cites W1808166775 @default.
- W2023161008 cites W1808274805 @default.
- W2023161008 cites W1834162491 @default.
- W2023161008 cites W1943757146 @default.
- W2023161008 cites W1961086932 @default.
- W2023161008 cites W1966182183 @default.
- W2023161008 cites W1968553255 @default.
- W2023161008 cites W1968852534 @default.
- W2023161008 cites W1970203334 @default.
- W2023161008 cites W1972070261 @default.
- W2023161008 cites W1972221169 @default.
- W2023161008 cites W1972376577 @default.
- W2023161008 cites W1973558008 @default.
- W2023161008 cites W1974156864 @default.
- W2023161008 cites W1979193198 @default.
- W2023161008 cites W1980232989 @default.
- W2023161008 cites W1985335015 @default.
- W2023161008 cites W1986091865 @default.
- W2023161008 cites W1986608501 @default.
- W2023161008 cites W1988055683 @default.
- W2023161008 cites W1988722391 @default.
- W2023161008 cites W1988749276 @default.
- W2023161008 cites W1995746794 @default.
- W2023161008 cites W1995749960 @default.
- W2023161008 cites W1996511633 @default.
- W2023161008 cites W1996710480 @default.
- W2023161008 cites W1996982755 @default.
- W2023161008 cites W1999136843 @default.
- W2023161008 cites W2001142218 @default.
- W2023161008 cites W2001243793 @default.
- W2023161008 cites W2003684417 @default.
- W2023161008 cites W2003858743 @default.
- W2023161008 cites W2004716765 @default.
- W2023161008 cites W2006249801 @default.
- W2023161008 cites W2008486253 @default.
- W2023161008 cites W2012143024 @default.
- W2023161008 cites W2012546083 @default.
- W2023161008 cites W2015635529 @default.
- W2023161008 cites W2015816779 @default.
- W2023161008 cites W2018168876 @default.
- W2023161008 cites W2019631946 @default.
- W2023161008 cites W2024285818 @default.
- W2023161008 cites W2025492930 @default.
- W2023161008 cites W2026338162 @default.
- W2023161008 cites W2026451260 @default.
- W2023161008 cites W2028831791 @default.
- W2023161008 cites W2030692398 @default.
- W2023161008 cites W2032463650 @default.
- W2023161008 cites W2033580461 @default.
- W2023161008 cites W2033691550 @default.
- W2023161008 cites W2034754449 @default.
- W2023161008 cites W2037835396 @default.
- W2023161008 cites W2042418839 @default.
- W2023161008 cites W2043736935 @default.
- W2023161008 cites W2046759679 @default.
- W2023161008 cites W2047083914 @default.
- W2023161008 cites W2048501423 @default.
- W2023161008 cites W2050002476 @default.
- W2023161008 cites W2052247149 @default.
- W2023161008 cites W2052423003 @default.
- W2023161008 cites W2052769426 @default.
- W2023161008 cites W2054756742 @default.
- W2023161008 cites W2066576784 @default.
- W2023161008 cites W2066994895 @default.
- W2023161008 cites W2068875641 @default.
- W2023161008 cites W2069585118 @default.
- W2023161008 cites W2070605565 @default.
- W2023161008 cites W2070841721 @default.
- W2023161008 cites W2073674120 @default.
- W2023161008 cites W2074455521 @default.
- W2023161008 cites W2077151111 @default.
- W2023161008 cites W2078629571 @default.
- W2023161008 cites W2081603312 @default.
- W2023161008 cites W2082361721 @default.
- W2023161008 cites W2082715693 @default.
- W2023161008 cites W2084776708 @default.
- W2023161008 cites W2085951419 @default.
- W2023161008 cites W2087423729 @default.
- W2023161008 cites W2089406515 @default.
- W2023161008 cites W2091061672 @default.
- W2023161008 cites W2091181726 @default.
- W2023161008 cites W2091284200 @default.
- W2023161008 cites W2091505364 @default.