Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023161568> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2023161568 endingPage "635" @default.
- W2023161568 startingPage "632" @default.
- W2023161568 abstract "Summary. The management of acute and surgical bleeding episodes in children with severe factor VIII or IX deficiency who develop high responding inhibitors presents a major therapeutic challenge to clinicians. Recombinant factor VIIa (rVIIa) is an effective, reliable and safe treatment that can be used to treat acute bleeding episodes prior to commencing an immune tolerance programme and to cover surgical procedures until the immune tolerance programme is successful. In a significant minority of patients, immune tolerance therapy is ineffective and an alternative haemostatic agent such as rVIIa is required for life‐long treatment. The present study evaluated the use of rVIIa in a paediatric setting. Twelve children, aged 1–16 years, were treated successfully with rVIIa to prevent surgical bleeding in 20 surgical procedures (19 central venous access device insertion or removal, 1 dental extraction). Minor postoperative haematomata developed in 2 out of 20 cases after regular rVIIa therapy had been discontinued and resolved with a short course of rVIIa in both cases. Three children had six life‐ or limb‐threatening bleeding episodes. All bleeding episodes resolved with regular rVIIa treatment although topical fibrin glue was needed in one child with a frenulum tear. One patient required two red cell transfusions for symptomatic anaemia resulting from two separate bleeding episodes. The rVIIa therapy was well tolerated and there was no evidence of treatment‐related complications. We conclude that rVIIa is the treatment of choice for the management of surgery and acute life‐ or limb‐threatening bleeding in children with haemophilia and high responding inhibitors." @default.
- W2023161568 created "2016-06-24" @default.
- W2023161568 creator A5004954447 @default.
- W2023161568 creator A5042469434 @default.
- W2023161568 creator A5045474639 @default.
- W2023161568 creator A5046036494 @default.
- W2023161568 creator A5055945057 @default.
- W2023161568 creator A5059264212 @default.
- W2023161568 creator A5076346456 @default.
- W2023161568 date "2002-03-01" @default.
- W2023161568 modified "2023-10-17" @default.
- W2023161568 title "Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors" @default.
- W2023161568 cites W1528709070 @default.
- W2023161568 cites W1888008068 @default.
- W2023161568 cites W1964469550 @default.
- W2023161568 cites W1979395666 @default.
- W2023161568 cites W1988236979 @default.
- W2023161568 cites W2022033278 @default.
- W2023161568 cites W2073958685 @default.
- W2023161568 cites W2085753698 @default.
- W2023161568 cites W2095425413 @default.
- W2023161568 cites W2103793215 @default.
- W2023161568 cites W2148505112 @default.
- W2023161568 cites W2168277287 @default.
- W2023161568 cites W2328158590 @default.
- W2023161568 cites W3028310968 @default.
- W2023161568 cites W4232904599 @default.
- W2023161568 cites W4248502612 @default.
- W2023161568 doi "https://doi.org/10.1046/j.0007-1048.2001.03324.x" @default.
- W2023161568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11849223" @default.
- W2023161568 hasPublicationYear "2002" @default.
- W2023161568 type Work @default.
- W2023161568 sameAs 2023161568 @default.
- W2023161568 citedByCount "44" @default.
- W2023161568 countsByYear W20231615682012 @default.
- W2023161568 countsByYear W20231615682013 @default.
- W2023161568 countsByYear W20231615682014 @default.
- W2023161568 countsByYear W20231615682017 @default.
- W2023161568 countsByYear W20231615682018 @default.
- W2023161568 countsByYear W20231615682019 @default.
- W2023161568 countsByYear W20231615682021 @default.
- W2023161568 countsByYear W20231615682023 @default.
- W2023161568 crossrefType "journal-article" @default.
- W2023161568 hasAuthorship W2023161568A5004954447 @default.
- W2023161568 hasAuthorship W2023161568A5042469434 @default.
- W2023161568 hasAuthorship W2023161568A5045474639 @default.
- W2023161568 hasAuthorship W2023161568A5046036494 @default.
- W2023161568 hasAuthorship W2023161568A5055945057 @default.
- W2023161568 hasAuthorship W2023161568A5059264212 @default.
- W2023161568 hasAuthorship W2023161568A5076346456 @default.
- W2023161568 hasBestOaLocation W20231615681 @default.
- W2023161568 hasConcept C126322002 @default.
- W2023161568 hasConcept C141071460 @default.
- W2023161568 hasConcept C2777232031 @default.
- W2023161568 hasConcept C2778385053 @default.
- W2023161568 hasConcept C2778780528 @default.
- W2023161568 hasConcept C2778961111 @default.
- W2023161568 hasConcept C2779394231 @default.
- W2023161568 hasConcept C2779936836 @default.
- W2023161568 hasConcept C71924100 @default.
- W2023161568 hasConcept C89560881 @default.
- W2023161568 hasConceptScore W2023161568C126322002 @default.
- W2023161568 hasConceptScore W2023161568C141071460 @default.
- W2023161568 hasConceptScore W2023161568C2777232031 @default.
- W2023161568 hasConceptScore W2023161568C2778385053 @default.
- W2023161568 hasConceptScore W2023161568C2778780528 @default.
- W2023161568 hasConceptScore W2023161568C2778961111 @default.
- W2023161568 hasConceptScore W2023161568C2779394231 @default.
- W2023161568 hasConceptScore W2023161568C2779936836 @default.
- W2023161568 hasConceptScore W2023161568C71924100 @default.
- W2023161568 hasConceptScore W2023161568C89560881 @default.
- W2023161568 hasIssue "3" @default.
- W2023161568 hasLocation W20231615681 @default.
- W2023161568 hasLocation W20231615682 @default.
- W2023161568 hasOpenAccess W2023161568 @default.
- W2023161568 hasPrimaryLocation W20231615681 @default.
- W2023161568 hasRelatedWork W1966293352 @default.
- W2023161568 hasRelatedWork W1995822104 @default.
- W2023161568 hasRelatedWork W2005719195 @default.
- W2023161568 hasRelatedWork W2067082011 @default.
- W2023161568 hasRelatedWork W2101928171 @default.
- W2023161568 hasRelatedWork W2106659439 @default.
- W2023161568 hasRelatedWork W2166990743 @default.
- W2023161568 hasRelatedWork W3113163854 @default.
- W2023161568 hasRelatedWork W3155450815 @default.
- W2023161568 hasRelatedWork W4233505807 @default.
- W2023161568 hasVolume "116" @default.
- W2023161568 isParatext "false" @default.
- W2023161568 isRetracted "false" @default.
- W2023161568 magId "2023161568" @default.
- W2023161568 workType "article" @default.