FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023162539> ?p ?o ?g. }

• W2023162539 endingPage "106" @default.
• W2023162539 startingPage "97" @default.
• W2023162539 abstract "In an attempt to identify endogenous chemicals producing DNA–protein crosslinks, we have studied in vitro crosslinking potential of malondialdehyde, a bifunctional chemical that is ubiquitously formed as a product of lipid peroxidation of polyunsaturated fatty acids. We have found that malondialdehyde readily forms crosslinks between DNA and histones under physiological ionic and pH conditions. Formation of DNA–protein crosslinks was limited to proteins that were able to bind to DNA. Malondialdehyde failed to form DNA–protein crosslinks when histone binding to DNA was prevented by elevated ionic strength or when bovine serum albumin was used in the reaction mixture. Malondialdehyde-produced DNA–histone crosslinks were relatively stable at 37°C with t1/2=13.4 days. Crosslinking of histones to DNA proceeds through the initial formation of protein adduct followed by reaction with DNA. Modification of DNA by malondialdehyde does not lead to a subsequent crosslinking of proteins. Significant formation of DNA–protein crosslinks was also registered in isolated kidney and liver nuclei treated with malondialdehyde. Based on its reactivity and stability of the resulting crosslinks, it is suggested that malondialdehyde could be one of the significant sources of endogenous DNA–protein crosslinks." @default.
• W2023162539 created "2016-06-24" @default.
• W2023162539 creator A5052707482 @default.
• W2023162539 creator A5078835331 @default.
• W2023162539 date "1999-03-01" @default.
• W2023162539 modified "2023-09-28" @default.
• W2023162539 title "Analysis of DNA–protein crosslinking activity of malondialdehyde in vitro" @default.
• W2023162539 cites W1965796676 @default.
• W2023162539 cites W1972986657 @default.
• W2023162539 cites W1974310748 @default.
• W2023162539 cites W1984628729 @default.
• W2023162539 cites W1995933703 @default.
• W2023162539 cites W2005929053 @default.
• W2023162539 cites W2010055022 @default.
• W2023162539 cites W2010373170 @default.
• W2023162539 cites W2015287095 @default.
• W2023162539 cites W2018341352 @default.
• W2023162539 cites W2018492549 @default.
• W2023162539 cites W2022520864 @default.
• W2023162539 cites W2023373172 @default.
• W2023162539 cites W2023428439 @default.
• W2023162539 cites W2031412848 @default.
• W2023162539 cites W2032769158 @default.
• W2023162539 cites W2033304530 @default.
• W2023162539 cites W2042613179 @default.
• W2023162539 cites W2042908630 @default.
• W2023162539 cites W2056810217 @default.
• W2023162539 cites W2063714049 @default.
• W2023162539 cites W2064680640 @default.
• W2023162539 cites W2075479169 @default.
• W2023162539 cites W2082169793 @default.
• W2023162539 cites W2083380425 @default.
• W2023162539 cites W2089293184 @default.
• W2023162539 cites W2095301528 @default.
• W2023162539 cites W2099114692 @default.
• W2023162539 cites W2099481136 @default.
• W2023162539 cites W2116743480 @default.
• W2023162539 cites W2125608251 @default.
• W2023162539 cites W2126616568 @default.
• W2023162539 cites W2127064404 @default.
• W2023162539 cites W2134200987 @default.
• W2023162539 cites W2135003369 @default.
• W2023162539 cites W2166174738 @default.
• W2023162539 cites W2166778877 @default.
• W2023162539 cites W592113389 @default.
• W2023162539 doi "https://doi.org/10.1016/s0027-5107(99)00011-1" @default.
• W2023162539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10064853" @default.
• W2023162539 hasPublicationYear "1999" @default.
• W2023162539 type Work @default.
• W2023162539 sameAs 2023162539 @default.
• W2023162539 citedByCount "89" @default.
• W2023162539 countsByYear W20231625392012 @default.
• W2023162539 countsByYear W20231625392013 @default.
• W2023162539 countsByYear W20231625392014 @default.
• W2023162539 countsByYear W20231625392015 @default.
• W2023162539 countsByYear W20231625392016 @default.
• W2023162539 countsByYear W20231625392017 @default.
• W2023162539 countsByYear W20231625392018 @default.
• W2023162539 countsByYear W20231625392019 @default.
• W2023162539 countsByYear W20231625392020 @default.
• W2023162539 countsByYear W20231625392021 @default.
• W2023162539 countsByYear W20231625392023 @default.
• W2023162539 crossrefType "journal-article" @default.
• W2023162539 hasAuthorship W2023162539A5052707482 @default.
• W2023162539 hasAuthorship W2023162539A5078835331 @default.
• W2023162539 hasConcept C181199279 @default.
• W2023162539 hasConcept C185592680 @default.
• W2023162539 hasConcept C2776151105 @default.
• W2023162539 hasConcept C2778401633 @default.
• W2023162539 hasConcept C2780829032 @default.
• W2023162539 hasConcept C552990157 @default.
• W2023162539 hasConcept C55493867 @default.
• W2023162539 hasConcept C64927066 @default.
• W2023162539 hasConceptScore W2023162539C181199279 @default.
• W2023162539 hasConceptScore W2023162539C185592680 @default.
• W2023162539 hasConceptScore W2023162539C2776151105 @default.
• W2023162539 hasConceptScore W2023162539C2778401633 @default.
• W2023162539 hasConceptScore W2023162539C2780829032 @default.
• W2023162539 hasConceptScore W2023162539C552990157 @default.
• W2023162539 hasConceptScore W2023162539C55493867 @default.
• W2023162539 hasConceptScore W2023162539C64927066 @default.
• W2023162539 hasIssue "1-2" @default.
• W2023162539 hasLocation W20231625391 @default.
• W2023162539 hasLocation W20231625392 @default.
• W2023162539 hasOpenAccess W2023162539 @default.
• W2023162539 hasPrimaryLocation W20231625391 @default.
• W2023162539 hasRelatedWork W1970341298 @default.
• W2023162539 hasRelatedWork W2019556559 @default.
• W2023162539 hasRelatedWork W2024177211 @default.
• W2023162539 hasRelatedWork W2040985455 @default.
• W2023162539 hasRelatedWork W2155244507 @default.
• W2023162539 hasRelatedWork W2163243996 @default.
• W2023162539 hasRelatedWork W2302273425 @default.
• W2023162539 hasRelatedWork W2418761910 @default.
• W2023162539 hasRelatedWork W2889703227 @default.
• W2023162539 hasRelatedWork W2998680540 @default.
• W2023162539 hasVolume "424" @default.
• W2023162539 isParatext "false" @default.

• next