FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023162706> ?p ?o ?g. }

• W2023162706 endingPage "2468" @default.
• W2023162706 startingPage "2457" @default.
• W2023162706 abstract "We report the identification of three new transcription regulatory elements that are associated with muscle gene expression in the nematode Caenorhabditis elegans. Starting from a subset of well-characterized nematode muscle genes, we identified conserved DNA motifs in the promoter regions using computational DNA pattern-recognition algorithms. These were considered to be putative muscle transcription regulatory motifs. Using the green-fluorescent protein (GFP) as a reporter, experiments were done to determine the biological activity of these motifs in driving muscle gene expression. Prediction accuracy of muscle expression based on the presence of these three motifs was encouraging; nine of 10 previously uncharacterized genes that were predicted to have muscle expression were shown to be expressed either specifically or selectively in the muscle tissues, whereas only one of the nine that scored low for these motifs expressed in muscle. Knockouts of putative regulatory elements in the promoter of the mlc-2 and unc-89 genes show that they significantly contribute to muscle expression and act in a synergistic manner. We find that these DNA motifs are also present in the muscle promoters of C. briggsae, indicating that they are functionally conserved in the nematodes." @default.
• W2023162706 created "2016-06-24" @default.
• W2023162706 creator A5008282916 @default.
• W2023162706 creator A5021949321 @default.
• W2023162706 creator A5040496643 @default.
• W2023162706 creator A5074206499 @default.
• W2023162706 date "2004-12-01" @default.
• W2023162706 modified "2023-09-23" @default.
• W2023162706 title "Novel transcription regulatory elements in<i>Caenorhabditis elegans</i>muscle genes" @default.
• W2023162706 cites W1498410508 @default.
• W2023162706 cites W1505968636 @default.
• W2023162706 cites W1587671188 @default.
• W2023162706 cites W1967161878 @default.
• W2023162706 cites W1972978214 @default.
• W2023162706 cites W1974690044 @default.
• W2023162706 cites W1991653341 @default.
• W2023162706 cites W2003967338 @default.
• W2023162706 cites W2006951466 @default.
• W2023162706 cites W2008900336 @default.
• W2023162706 cites W2009566340 @default.
• W2023162706 cites W2011490248 @default.
• W2023162706 cites W2032548898 @default.
• W2023162706 cites W2032579724 @default.
• W2023162706 cites W2034924573 @default.
• W2023162706 cites W2037940015 @default.
• W2023162706 cites W2041877620 @default.
• W2023162706 cites W2057909993 @default.
• W2023162706 cites W2057998009 @default.
• W2023162706 cites W2064384066 @default.
• W2023162706 cites W2065482981 @default.
• W2023162706 cites W2068011423 @default.
• W2023162706 cites W2074703985 @default.
• W2023162706 cites W2076751679 @default.
• W2023162706 cites W2090415636 @default.
• W2023162706 cites W2107768450 @default.
• W2023162706 cites W2112221859 @default.
• W2023162706 cites W2116362436 @default.
• W2023162706 cites W2116672274 @default.
• W2023162706 cites W2116688916 @default.
• W2023162706 cites W2118042193 @default.
• W2023162706 cites W2122163057 @default.
• W2023162706 cites W2122458935 @default.
• W2023162706 cites W2135221645 @default.
• W2023162706 cites W2135603226 @default.
• W2023162706 cites W2137428312 @default.
• W2023162706 cites W2138717237 @default.
• W2023162706 cites W2147014356 @default.
• W2023162706 cites W2149769193 @default.
• W2023162706 cites W2151464048 @default.
• W2023162706 cites W2165735666 @default.
• W2023162706 cites W2166277117 @default.
• W2023162706 cites W2166760188 @default.
• W2023162706 cites W2166898290 @default.
• W2023162706 cites W2168157737 @default.
• W2023162706 cites W2168786813 @default.
• W2023162706 cites W2171247261 @default.
• W2023162706 cites W2181856146 @default.
• W2023162706 cites W2186779150 @default.
• W2023162706 cites W4229799243 @default.
• W2023162706 doi "https://doi.org/10.1101/gr.2961104" @default.
• W2023162706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/534670" @default.
• W2023162706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15574824" @default.
• W2023162706 hasPublicationYear "2004" @default.
• W2023162706 type Work @default.
• W2023162706 sameAs 2023162706 @default.
• W2023162706 citedByCount "28" @default.
• W2023162706 countsByYear W20231627062012 @default.
• W2023162706 countsByYear W20231627062015 @default.
• W2023162706 countsByYear W20231627062018 @default.
• W2023162706 countsByYear W20231627062022 @default.
• W2023162706 countsByYear W20231627062023 @default.
• W2023162706 crossrefType "journal-article" @default.
• W2023162706 hasAuthorship W2023162706A5008282916 @default.
• W2023162706 hasAuthorship W2023162706A5021949321 @default.
• W2023162706 hasAuthorship W2023162706A5040496643 @default.
• W2023162706 hasAuthorship W2023162706A5074206499 @default.
• W2023162706 hasBestOaLocation W20231627061 @default.
• W2023162706 hasConcept C101762097 @default.
• W2023162706 hasConcept C104317684 @default.
• W2023162706 hasConcept C138885662 @default.
• W2023162706 hasConcept C150194340 @default.
• W2023162706 hasConcept C161733203 @default.
• W2023162706 hasConcept C165864922 @default.
• W2023162706 hasConcept C167625842 @default.
• W2023162706 hasConcept C179926584 @default.
• W2023162706 hasConcept C199216141 @default.
• W2023162706 hasConcept C21592294 @default.
• W2023162706 hasConcept C2778944004 @default.
• W2023162706 hasConcept C41895202 @default.
• W2023162706 hasConcept C54355233 @default.
• W2023162706 hasConcept C86339819 @default.
• W2023162706 hasConcept C86803240 @default.
• W2023162706 hasConcept C95444343 @default.
• W2023162706 hasConceptScore W2023162706C101762097 @default.
• W2023162706 hasConceptScore W2023162706C104317684 @default.
• W2023162706 hasConceptScore W2023162706C138885662 @default.
• W2023162706 hasConceptScore W2023162706C150194340 @default.
• W2023162706 hasConceptScore W2023162706C161733203 @default.

• next