Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023162910> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2023162910 endingPage "592" @default.
- W2023162910 startingPage "589" @default.
- W2023162910 abstract "The percutaneous absorption of amethocaine has been measured for different concentrations of the drug in three different formulations, A, B and C. Statistical analysis indicated that a concentration of 4% produced effective percutaneous local anaesthesia to pin-prick, together with an acceptable onset time of approximately 40 min. Increasing the concentration did not reduce the onset time further, although there was some increase in the duration of anaesthesia. Formulations A and B were hydrophilic, whereas C was an oil-in-water cream. Effective anaesthesia with formulation C required a higher drug concentration (12%), perhaps because of partitioning of the lipophilic anaesthetic into the lipid phase of the vehicle. The rate-limiting step was considered to be diffusion by the lipophilic anaesthetic through the stratum corneum, shown by onset of anaesthesia after removal of the formulation from the test site." @default.
- W2023162910 created "2016-06-24" @default.
- W2023162910 creator A5027702543 @default.
- W2023162910 creator A5051168977 @default.
- W2023162910 creator A5072940557 @default.
- W2023162910 creator A5080504478 @default.
- W2023162910 date "1988-11-01" @default.
- W2023162910 modified "2023-10-16" @default.
- W2023162910 title "CONCENTRATION-RESPONSE ANALYSIS OF PERCUTANEOUS LOCAL ANAESTHETIC FORMULATIONS" @default.
- W2023162910 cites W1597268672 @default.
- W2023162910 cites W1970784023 @default.
- W2023162910 cites W2022399868 @default.
- W2023162910 cites W2069981596 @default.
- W2023162910 cites W2079758895 @default.
- W2023162910 cites W2400515827 @default.
- W2023162910 cites W2401336855 @default.
- W2023162910 cites W2403040139 @default.
- W2023162910 doi "https://doi.org/10.1093/bja/61.5.589" @default.
- W2023162910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3207529" @default.
- W2023162910 hasPublicationYear "1988" @default.
- W2023162910 type Work @default.
- W2023162910 sameAs 2023162910 @default.
- W2023162910 citedByCount "29" @default.
- W2023162910 countsByYear W20231629102013 @default.
- W2023162910 countsByYear W20231629102015 @default.
- W2023162910 countsByYear W20231629102017 @default.
- W2023162910 crossrefType "journal-article" @default.
- W2023162910 hasAuthorship W2023162910A5027702543 @default.
- W2023162910 hasAuthorship W2023162910A5051168977 @default.
- W2023162910 hasAuthorship W2023162910A5072940557 @default.
- W2023162910 hasAuthorship W2023162910A5080504478 @default.
- W2023162910 hasBestOaLocation W20231629101 @default.
- W2023162910 hasConcept C125287762 @default.
- W2023162910 hasConcept C141071460 @default.
- W2023162910 hasConcept C142724271 @default.
- W2023162910 hasConcept C159985019 @default.
- W2023162910 hasConcept C185592680 @default.
- W2023162910 hasConcept C186060115 @default.
- W2023162910 hasConcept C192562407 @default.
- W2023162910 hasConcept C2778370115 @default.
- W2023162910 hasConcept C2780813298 @default.
- W2023162910 hasConcept C2993377847 @default.
- W2023162910 hasConcept C3017770426 @default.
- W2023162910 hasConcept C42219234 @default.
- W2023162910 hasConcept C43617362 @default.
- W2023162910 hasConcept C71924100 @default.
- W2023162910 hasConcept C86803240 @default.
- W2023162910 hasConceptScore W2023162910C125287762 @default.
- W2023162910 hasConceptScore W2023162910C141071460 @default.
- W2023162910 hasConceptScore W2023162910C142724271 @default.
- W2023162910 hasConceptScore W2023162910C159985019 @default.
- W2023162910 hasConceptScore W2023162910C185592680 @default.
- W2023162910 hasConceptScore W2023162910C186060115 @default.
- W2023162910 hasConceptScore W2023162910C192562407 @default.
- W2023162910 hasConceptScore W2023162910C2778370115 @default.
- W2023162910 hasConceptScore W2023162910C2780813298 @default.
- W2023162910 hasConceptScore W2023162910C2993377847 @default.
- W2023162910 hasConceptScore W2023162910C3017770426 @default.
- W2023162910 hasConceptScore W2023162910C42219234 @default.
- W2023162910 hasConceptScore W2023162910C43617362 @default.
- W2023162910 hasConceptScore W2023162910C71924100 @default.
- W2023162910 hasConceptScore W2023162910C86803240 @default.
- W2023162910 hasIssue "5" @default.
- W2023162910 hasLocation W20231629101 @default.
- W2023162910 hasLocation W20231629102 @default.
- W2023162910 hasOpenAccess W2023162910 @default.
- W2023162910 hasPrimaryLocation W20231629101 @default.
- W2023162910 hasRelatedWork W1992626593 @default.
- W2023162910 hasRelatedWork W2094727229 @default.
- W2023162910 hasRelatedWork W2121548049 @default.
- W2023162910 hasRelatedWork W2137048490 @default.
- W2023162910 hasRelatedWork W2376313638 @default.
- W2023162910 hasRelatedWork W2376445419 @default.
- W2023162910 hasRelatedWork W2395600221 @default.
- W2023162910 hasRelatedWork W2748952813 @default.
- W2023162910 hasRelatedWork W2899084033 @default.
- W2023162910 hasRelatedWork W4300549667 @default.
- W2023162910 hasVolume "61" @default.
- W2023162910 isParatext "false" @default.
- W2023162910 isRetracted "false" @default.
- W2023162910 magId "2023162910" @default.
- W2023162910 workType "article" @default.