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- W2023163614 abstract "RNA research has made great progress in recent years. A variety of unforeseen complexities have been identified, many with relevance to human brain disease. For example, neurologic illnesses may arise because of perturbations in distinct but interrelated tiers of RNA-based genetic regulation: pre-mRNA splicing; nonsplicing RNA modifications; and mRNA translational regulation. Furthermore, there is poor correlation between mRNA levels and protein levels in mammalian cells, due partly to complicated post-transcriptional regulation by hitherto unknown noncoding RNAs. Some noncoding RNAs have been shown to be involved in human brain diseases. Diseases potentially mediated by alterations in RNA processes include tauopathies, myotonic dystrophy, Alzheimer disease, brain cancer, and many others. Here we present an overview of new research highlighting functions for RNA that far surpass the messenger in the middle role and that identify RNA molecules as important agents in the human brain in health and in disease states." @default.
- W2023163614 created "2016-06-24" @default.
- W2023163614 creator A5011049890 @default.
- W2023163614 creator A5021996221 @default.
- W2023163614 date "2007-06-01" @default.
- W2023163614 modified "2023-10-10" @default.
- W2023163614 title "RNA in Brain Disease" @default.
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- W2023163614 doi "https://doi.org/10.1097/01.jnen.0000240474.27791.f3" @default.
- W2023163614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17549006" @default.
- W2023163614 hasPublicationYear "2007" @default.
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