Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023164051> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2023164051 abstract "Elevated plasma levels of apolipoprotein A1 (APO-A1) and high-density lipoprotein cholesterol (HDL-C) are important protective factors for atherosclerosis and coronary heart disease. Using the data on plasma concentrations of APO-A1, and HDL-C particles HDL2-C and HDL3-C in 970 Israeli individuals belonging to 228 pedigrees, we tested the hypothesis that a major locus influencing interindividual variation in APO-A1 levels also controls interindividual variation in HDL3-C and HDL2-C levels. Univariate and bivariate complex segregation analyses, as implemented in two statistical packages (MAN-3 and PAP-4.0) were applied to test the hypothesis. The results of the analysis clearly indicated the possibility of major gene involvement in the determination of plasma concentration variation of each of the 3 study variables. The results provide strong evidence in support of our hypothesis that HDL3-C genetic variation fully depends on the APO-A1 major locus. In particular, environmental and sporadic models were strongly rejected (P < 0.001) in bivariate analysis. The hypothesis of no pleiotropic effect of the putative APO-A1 locus on HDL3-C transmission was also unequivocally rejected (P < 0.001), while the bivariate Mendelian model was accepted (P > 0.05). The results of bivariate analysis of APO-A1 effect on HDL2-C were not clear. They indicated the possibility of the existence of slight genetic covariation between the two variables, and as yet we were unable to decipher the mode of covariation with the applied models." @default.
- W2023164051 created "2016-06-24" @default.
- W2023164051 creator A5033865780 @default.
- W2023164051 creator A5040476761 @default.
- W2023164051 creator A5043575891 @default.
- W2023164051 creator A5048483934 @default.
- W2023164051 creator A5064866455 @default.
- W2023164051 creator A5082209014 @default.
- W2023164051 date "1998-01-01" @default.
- W2023164051 modified "2023-10-14" @default.
- W2023164051 title "Major locus influencing plasma APO-A1 levels also controls plasma HDL3-C concentrations" @default.
- W2023164051 cites W1555687812 @default.
- W2023164051 cites W1903183894 @default.
- W2023164051 cites W1932595303 @default.
- W2023164051 cites W1954449899 @default.
- W2023164051 cites W1966594148 @default.
- W2023164051 cites W1983299984 @default.
- W2023164051 cites W1991311566 @default.
- W2023164051 cites W2021171609 @default.
- W2023164051 cites W2033357264 @default.
- W2023164051 cites W2056011078 @default.
- W2023164051 cites W2056774916 @default.
- W2023164051 cites W2064707131 @default.
- W2023164051 cites W2066522801 @default.
- W2023164051 cites W2105037838 @default.
- W2023164051 cites W2119026555 @default.
- W2023164051 cites W2123761727 @default.
- W2023164051 cites W2144446479 @default.
- W2023164051 cites W2147916821 @default.
- W2023164051 doi "https://doi.org/10.1002/(sici)1098-2272(1998)15:3<237::aid-gepi3>3.0.co;2-1" @default.
- W2023164051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9593111" @default.
- W2023164051 hasPublicationYear "1998" @default.
- W2023164051 type Work @default.
- W2023164051 sameAs 2023164051 @default.
- W2023164051 citedByCount "2" @default.
- W2023164051 crossrefType "journal-article" @default.
- W2023164051 hasAuthorship W2023164051A5033865780 @default.
- W2023164051 hasAuthorship W2023164051A5040476761 @default.
- W2023164051 hasAuthorship W2023164051A5043575891 @default.
- W2023164051 hasAuthorship W2023164051A5048483934 @default.
- W2023164051 hasAuthorship W2023164051A5064866455 @default.
- W2023164051 hasAuthorship W2023164051A5082209014 @default.
- W2023164051 hasConcept C104317684 @default.
- W2023164051 hasConcept C105795698 @default.
- W2023164051 hasConcept C126322002 @default.
- W2023164051 hasConcept C134018914 @default.
- W2023164051 hasConcept C144301174 @default.
- W2023164051 hasConcept C175783326 @default.
- W2023164051 hasConcept C22593422 @default.
- W2023164051 hasConcept C2776547343 @default.
- W2023164051 hasConcept C2778163477 @default.
- W2023164051 hasConcept C2780072125 @default.
- W2023164051 hasConcept C33923547 @default.
- W2023164051 hasConcept C38180746 @default.
- W2023164051 hasConcept C54355233 @default.
- W2023164051 hasConcept C62746215 @default.
- W2023164051 hasConcept C64341305 @default.
- W2023164051 hasConcept C71924100 @default.
- W2023164051 hasConcept C84597430 @default.
- W2023164051 hasConcept C86803240 @default.
- W2023164051 hasConceptScore W2023164051C104317684 @default.
- W2023164051 hasConceptScore W2023164051C105795698 @default.
- W2023164051 hasConceptScore W2023164051C126322002 @default.
- W2023164051 hasConceptScore W2023164051C134018914 @default.
- W2023164051 hasConceptScore W2023164051C144301174 @default.
- W2023164051 hasConceptScore W2023164051C175783326 @default.
- W2023164051 hasConceptScore W2023164051C22593422 @default.
- W2023164051 hasConceptScore W2023164051C2776547343 @default.
- W2023164051 hasConceptScore W2023164051C2778163477 @default.
- W2023164051 hasConceptScore W2023164051C2780072125 @default.
- W2023164051 hasConceptScore W2023164051C33923547 @default.
- W2023164051 hasConceptScore W2023164051C38180746 @default.
- W2023164051 hasConceptScore W2023164051C54355233 @default.
- W2023164051 hasConceptScore W2023164051C62746215 @default.
- W2023164051 hasConceptScore W2023164051C64341305 @default.
- W2023164051 hasConceptScore W2023164051C71924100 @default.
- W2023164051 hasConceptScore W2023164051C84597430 @default.
- W2023164051 hasConceptScore W2023164051C86803240 @default.
- W2023164051 hasLocation W20231640511 @default.
- W2023164051 hasLocation W20231640512 @default.
- W2023164051 hasOpenAccess W2023164051 @default.
- W2023164051 hasPrimaryLocation W20231640511 @default.
- W2023164051 hasRelatedWork W1944525796 @default.
- W2023164051 hasRelatedWork W1964114439 @default.
- W2023164051 hasRelatedWork W1977936045 @default.
- W2023164051 hasRelatedWork W1991652655 @default.
- W2023164051 hasRelatedWork W1997730450 @default.
- W2023164051 hasRelatedWork W2025970721 @default.
- W2023164051 hasRelatedWork W2057739827 @default.
- W2023164051 hasRelatedWork W2123761727 @default.
- W2023164051 hasRelatedWork W2140442125 @default.
- W2023164051 hasRelatedWork W3152267210 @default.
- W2023164051 isParatext "false" @default.
- W2023164051 isRetracted "false" @default.
- W2023164051 magId "2023164051" @default.
- W2023164051 workType "article" @default.