Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023164092> ?p ?o ?g. }
- W2023164092 endingPage "1198" @default.
- W2023164092 startingPage "1189" @default.
- W2023164092 abstract "Abstract —Many protein-tyrosine phosphatases (PTPases) have now been identified, but little is known about PTPase expression and regulation in vascular tissue and in vascular disease. Polymerase chain reaction (PCR) amplification and cDNA fingerprinting of PTPase catalytic domains, combined with random sequencing of PCR product libraries, identified 18 (8 receptor-like and 10 cytosolic) PTPases in the rat carotid artery and revealed differential expression of 5 of these PTPases during neointima formation after balloon catheter injury. In situ hybridization was used to localize mRNA expression in vessel cross sections for the 5 differentially expressed PTPases. This revealed that for 3 PTPases (SHP1, CD45, and PTPβ), differential transcript abundance was due to appearance/loss of the cell types by which they were expressed (leukocytes for SHP1 and CD45, endothelial cells for PTPβ). However, mRNA expression of 2 PTPases (PTPL1 and PTP1B) was specifically upregulated by proliferating and migrating smooth muscle cells (SMCs) in characteristic temporal and regional patterns in response to vessel damage. Quantitative PCR analysis showed that PTP1B and PTPL1 were induced ≈30-fold and ≈60-fold, respectively, by 2 weeks after injury in the damaged vessels compared with the uninjured vessels. PTP1B was rapidly upregulated in the media after vessel injury and remained highly expressed in the developing neointima. By contrast, PTPL1 expression did not increase dramatically until the SMCs had migrated into the intima. The differential expression of PTP1B and PTPL1 by SMCs after injury suggests roles for these PTPases in the regulation of vessel wall remodeling." @default.
- W2023164092 created "2016-06-24" @default.
- W2023164092 creator A5048344255 @default.
- W2023164092 creator A5070441005 @default.
- W2023164092 creator A5080417828 @default.
- W2023164092 date "2000-05-01" @default.
- W2023164092 modified "2023-09-27" @default.
- W2023164092 title "Protein-Tyrosine Phosphatases in the Vessel Wall" @default.
- W2023164092 cites W1487612553 @default.
- W2023164092 cites W1497274503 @default.
- W2023164092 cites W1504159440 @default.
- W2023164092 cites W1539002651 @default.
- W2023164092 cites W1552451078 @default.
- W2023164092 cites W1561809228 @default.
- W2023164092 cites W1599255496 @default.
- W2023164092 cites W1653069047 @default.
- W2023164092 cites W1692715431 @default.
- W2023164092 cites W1778557300 @default.
- W2023164092 cites W1790227735 @default.
- W2023164092 cites W1969318766 @default.
- W2023164092 cites W1970770376 @default.
- W2023164092 cites W1983778842 @default.
- W2023164092 cites W1988130438 @default.
- W2023164092 cites W1989756421 @default.
- W2023164092 cites W2004755427 @default.
- W2023164092 cites W2004782235 @default.
- W2023164092 cites W2012514869 @default.
- W2023164092 cites W2013012232 @default.
- W2023164092 cites W2013355944 @default.
- W2023164092 cites W2014129040 @default.
- W2023164092 cites W2015219342 @default.
- W2023164092 cites W2022249390 @default.
- W2023164092 cites W2022506262 @default.
- W2023164092 cites W2026578815 @default.
- W2023164092 cites W2031835983 @default.
- W2023164092 cites W2032403819 @default.
- W2023164092 cites W2073128787 @default.
- W2023164092 cites W2090280060 @default.
- W2023164092 cites W2095722048 @default.
- W2023164092 cites W2098997742 @default.
- W2023164092 cites W2123229219 @default.
- W2023164092 cites W2126658684 @default.
- W2023164092 cites W2127130465 @default.
- W2023164092 cites W2134884900 @default.
- W2023164092 cites W2138270253 @default.
- W2023164092 cites W2142555803 @default.
- W2023164092 cites W2151915336 @default.
- W2023164092 cites W2213246173 @default.
- W2023164092 cites W2341662185 @default.
- W2023164092 cites W2415308954 @default.
- W2023164092 doi "https://doi.org/10.1161/01.atv.20.5.1189" @default.
- W2023164092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10807732" @default.
- W2023164092 hasPublicationYear "2000" @default.
- W2023164092 type Work @default.
- W2023164092 sameAs 2023164092 @default.
- W2023164092 citedByCount "32" @default.
- W2023164092 countsByYear W20231640922013 @default.
- W2023164092 countsByYear W20231640922014 @default.
- W2023164092 countsByYear W20231640922015 @default.
- W2023164092 countsByYear W20231640922016 @default.
- W2023164092 countsByYear W20231640922017 @default.
- W2023164092 countsByYear W20231640922019 @default.
- W2023164092 countsByYear W20231640922021 @default.
- W2023164092 countsByYear W20231640922022 @default.
- W2023164092 crossrefType "journal-article" @default.
- W2023164092 hasAuthorship W2023164092A5048344255 @default.
- W2023164092 hasAuthorship W2023164092A5070441005 @default.
- W2023164092 hasAuthorship W2023164092A5080417828 @default.
- W2023164092 hasBestOaLocation W20231640921 @default.
- W2023164092 hasConcept C104317684 @default.
- W2023164092 hasConcept C126322002 @default.
- W2023164092 hasConcept C127561419 @default.
- W2023164092 hasConcept C134018914 @default.
- W2023164092 hasConcept C150194340 @default.
- W2023164092 hasConcept C153911025 @default.
- W2023164092 hasConcept C187882448 @default.
- W2023164092 hasConcept C2776657240 @default.
- W2023164092 hasConcept C2777339539 @default.
- W2023164092 hasConcept C2778283817 @default.
- W2023164092 hasConcept C2778583881 @default.
- W2023164092 hasConcept C2779395532 @default.
- W2023164092 hasConcept C2992686903 @default.
- W2023164092 hasConcept C54355233 @default.
- W2023164092 hasConcept C62478195 @default.
- W2023164092 hasConcept C71924100 @default.
- W2023164092 hasConcept C81439078 @default.
- W2023164092 hasConcept C85528070 @default.
- W2023164092 hasConcept C86803240 @default.
- W2023164092 hasConcept C95444343 @default.
- W2023164092 hasConceptScore W2023164092C104317684 @default.
- W2023164092 hasConceptScore W2023164092C126322002 @default.
- W2023164092 hasConceptScore W2023164092C127561419 @default.
- W2023164092 hasConceptScore W2023164092C134018914 @default.
- W2023164092 hasConceptScore W2023164092C150194340 @default.
- W2023164092 hasConceptScore W2023164092C153911025 @default.
- W2023164092 hasConceptScore W2023164092C187882448 @default.
- W2023164092 hasConceptScore W2023164092C2776657240 @default.
- W2023164092 hasConceptScore W2023164092C2777339539 @default.