FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023165046> ?p ?o ?g. }

• W2023165046 abstract "Abstract Background The ability of living cells to respond appropriately to apoptosis signals is crucial for the proper development and homeostasis of multicellular organisms. For example, viable cells must be stable enough to appropriately respond to apoptosis signaling so that an irreversible death program is only induced when apoptosis signaling reaches a certain threshold. Previous studies have introduced bistability models in which signaling by caspase-3 activity represents a key regulator of cell fate in response to apoptosis stimuli. Results In this study, apoptosis induced by tumor necrosis factor (TNF) signaling is investigated, and a mathematical model without the requirement for bistability is proposed. In this model, rapid degradation of the active forms of caspases -8 and -3 are included, and TNF-signaling is found to induce a pulse of caspase-3 activation and trigger an irreversible death program. This result agrees with experimental observations. The ability of a cell to respond to, or resist, apoptosis stimuli is also discussed. Furthermore, the activation efficiencies of caspases -8 and -3 that are essential to a cell’s response to extracellular apoptosis stimuli are defined. Based on the simulations performed, it is observed that activation efficiencies must be sufficiently sensitive to appropriately compromise a cell’s resistance and effectiveness in response to apoptosis stimuli. Conclusions Our results suggest that bistability may not be a necessary condition for the induction of apoptosis by TNF signaling. Rather, a sharp increase in caspase-3 activity might be sufficient to trigger the induction of an irreversible death program. Accordingly, regulation of caspase activity and degradation of active caspases is essential for a cell’s response to apoptosis stimuli." @default.
• W2023165046 created "2016-06-24" @default.
• W2023165046 creator A5021871320 @default.
• W2023165046 creator A5031112847 @default.
• W2023165046 creator A5045594996 @default.
• W2023165046 creator A5090439768 @default.
• W2023165046 date "2011-06-20" @default.
• W2023165046 modified "2023-10-14" @default.
• W2023165046 title "A trigger model of apoptosis induced by tumor necrosis factor signaling" @default.
• W2023165046 cites W1492587973 @default.
• W2023165046 cites W1557686543 @default.
• W2023165046 cites W1745634660 @default.
• W2023165046 cites W1964037688 @default.
• W2023165046 cites W1970514669 @default.
• W2023165046 cites W1973109581 @default.
• W2023165046 cites W1976669514 @default.
• W2023165046 cites W1977715503 @default.
• W2023165046 cites W2002503549 @default.
• W2023165046 cites W2009347496 @default.
• W2023165046 cites W2010298858 @default.
• W2023165046 cites W2017728303 @default.
• W2023165046 cites W2034593795 @default.
• W2023165046 cites W2039597975 @default.
• W2023165046 cites W2056217426 @default.
• W2023165046 cites W2071755099 @default.
• W2023165046 cites W2077206871 @default.
• W2023165046 cites W2083992079 @default.
• W2023165046 cites W2100915449 @default.
• W2023165046 cites W2116875795 @default.
• W2023165046 cites W2120262606 @default.
• W2023165046 cites W2130988210 @default.
• W2023165046 cites W2131532199 @default.
• W2023165046 cites W2145611701 @default.
• W2023165046 cites W2152585118 @default.
• W2023165046 cites W2152826290 @default.
• W2023165046 cites W2156496263 @default.
• W2023165046 cites W2168639189 @default.
• W2023165046 cites W4234468600 @default.
• W2023165046 cites W4247673683 @default.
• W2023165046 doi "https://doi.org/10.1186/1752-0509-5-s1-s13" @default.
• W2023165046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3121113" @default.
• W2023165046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21689472" @default.
• W2023165046 hasPublicationYear "2011" @default.
• W2023165046 type Work @default.
• W2023165046 sameAs 2023165046 @default.
• W2023165046 citedByCount "14" @default.
• W2023165046 countsByYear W20231650462012 @default.
• W2023165046 countsByYear W20231650462013 @default.
• W2023165046 countsByYear W20231650462014 @default.
• W2023165046 countsByYear W20231650462015 @default.
• W2023165046 countsByYear W20231650462019 @default.
• W2023165046 countsByYear W20231650462023 @default.
• W2023165046 crossrefType "journal-article" @default.
• W2023165046 hasAuthorship W2023165046A5021871320 @default.
• W2023165046 hasAuthorship W2023165046A5031112847 @default.
• W2023165046 hasAuthorship W2023165046A5045594996 @default.
• W2023165046 hasAuthorship W2023165046A5090439768 @default.
• W2023165046 hasBestOaLocation W20231650461 @default.
• W2023165046 hasConcept C163421366 @default.
• W2023165046 hasConcept C17991360 @default.
• W2023165046 hasConcept C190283241 @default.
• W2023165046 hasConcept C192562407 @default.
• W2023165046 hasConcept C203014093 @default.
• W2023165046 hasConcept C31573885 @default.
• W2023165046 hasConcept C49040817 @default.
• W2023165046 hasConcept C55493867 @default.
• W2023165046 hasConcept C62478195 @default.
• W2023165046 hasConcept C86803240 @default.
• W2023165046 hasConcept C95444343 @default.
• W2023165046 hasConcept C97292510 @default.
• W2023165046 hasConcept C98424977 @default.
• W2023165046 hasConceptScore W2023165046C163421366 @default.
• W2023165046 hasConceptScore W2023165046C17991360 @default.
• W2023165046 hasConceptScore W2023165046C190283241 @default.
• W2023165046 hasConceptScore W2023165046C192562407 @default.
• W2023165046 hasConceptScore W2023165046C203014093 @default.
• W2023165046 hasConceptScore W2023165046C31573885 @default.
• W2023165046 hasConceptScore W2023165046C49040817 @default.
• W2023165046 hasConceptScore W2023165046C55493867 @default.
• W2023165046 hasConceptScore W2023165046C62478195 @default.
• W2023165046 hasConceptScore W2023165046C86803240 @default.
• W2023165046 hasConceptScore W2023165046C95444343 @default.
• W2023165046 hasConceptScore W2023165046C97292510 @default.
• W2023165046 hasConceptScore W2023165046C98424977 @default.
• W2023165046 hasIssue "S1" @default.
• W2023165046 hasLocation W20231650461 @default.
• W2023165046 hasLocation W20231650462 @default.
• W2023165046 hasLocation W20231650463 @default.
• W2023165046 hasOpenAccess W2023165046 @default.
• W2023165046 hasPrimaryLocation W20231650461 @default.
• W2023165046 hasRelatedWork W1967264415 @default.
• W2023165046 hasRelatedWork W19916217 @default.
• W2023165046 hasRelatedWork W2031840568 @default.
• W2023165046 hasRelatedWork W2065725081 @default.
• W2023165046 hasRelatedWork W2073254770 @default.
• W2023165046 hasRelatedWork W2074148448 @default.
• W2023165046 hasRelatedWork W2145626047 @default.
• W2023165046 hasRelatedWork W2352094157 @default.
• W2023165046 hasRelatedWork W2383263084 @default.
• W2023165046 hasRelatedWork W2594560619 @default.

• next