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• W2023165227 abstract "To evaluate the efficacy of long-term thalidomide treatment in cutaneous lesions of systemic lupus erythematosus (SLE), not responsive to conventional therapy.Were selected 18 SLE patients (ACR criteria) with active cutaneous lesions not responsive to chloroquine, photoprotectors and low doses prednisone and who presented good response to thalidomide but relapsed after withdrawal of the drug. All female patients had no risk of pregnancy. Thalidomide was reintroduced and maintained at low dose (25-100 mg/day) for a minimum of 6 months.Eighteen patients (16 females) with mean age of 34.2 yo (16-57 y.o.) received thalidomide for 6-21 months (mean 8.5 m). The mean dose of prednisone at beginning of study was 38.3 mg/d and at the end was 9.7 mg/d (p < 0.05). Complete remission of cutaneous lesions was observed in thirteen patients (72%) and partial remission in five (28%). Side effects observed were: drowsiness in eight patients, intestinal constipation in 5, transient oliguria in 1, paresthesia of hand with normal electromyography in another one. All side effects disappeared with reduction of thalidomide dose and no patient needed to stop treatment owing to side effect.Thalidomide is a good alternative therapy to SLE patients with refractory cutaneous lesions and without any risk of pregnancy." @default.
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• W2023165227 date "1998-12-01" @default.
• W2023165227 modified "2023-10-16" @default.
• W2023165227 title "Long-term thalidomide use in refractory cutaneous lesions of systemic lupus erythematosus" @default.
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• W2023165227 doi "https://doi.org/10.1590/s0104-42301998000400007" @default.
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