FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023165823> ?p ?o ?g. }

• W2023165823 endingPage "e50667" @default.
• W2023165823 startingPage "e50667" @default.
• W2023165823 abstract "The bacterial pathogen Salmonella causes worldwide disease. A major route of intestinal entry involves M cells, providing access to B cell-rich Peyer's Patches. Primary human B cells phagocytose Salmonella typhimurium upon recognition by the specific surface Ig receptor (BCR). As it is unclear how Salmonella disseminates systemically, we studied whether Salmonella can use B cells as a transport device for spreading.Human primary B cells or Ramos cell line were incubated with GFP-expressing Salmonella. Intracellular survival and escape was studied in vitro by live cell imaging, flow cytometry and flow imaging. HEL-specific B cells were transferred into C57BL/6 mice and HEL-expressing Salmonella spreading in vivo was analyzed investigating mesenteric lymph nodes, spleen and blood. After phagocytosis by B cells, Salmonella survives intracellularly in a non-replicative state which is actively maintained by the B cell. Salmonella is later excreted followed by reproductive infection of other cell types. Salmonella-specific B cells thus act both as a survival niche and a reservoir for reinfection. Adoptive transfer of antigen-specific B cells before oral infection of mice showed that these B cells mediate in vivo systemic spreading of Salmonella to spleen and blood.This is a first example of a pathogenic bacterium that abuses the antigen-specific cells of the adaptive immune system for systemic spreading for dissemination of infection." @default.
• W2023165823 created "2016-06-24" @default.
• W2023165823 creator A5009731605 @default.
• W2023165823 creator A5014820060 @default.
• W2023165823 creator A5024990785 @default.
• W2023165823 creator A5027634416 @default.
• W2023165823 creator A5043648102 @default.
• W2023165823 creator A5046971648 @default.
• W2023165823 creator A5059194884 @default.
• W2023165823 creator A5060457244 @default.
• W2023165823 creator A5069860717 @default.
• W2023165823 creator A5084531530 @default.
• W2023165823 creator A5085944050 @default.
• W2023165823 date "2012-11-29" @default.
• W2023165823 modified "2023-10-17" @default.
• W2023165823 title "Selective Infection of Antigen-Specific B Lymphocytes by Salmonella Mediates Bacterial Survival and Systemic Spreading of Infection" @default.
• W2023165823 cites W1649341603 @default.
• W2023165823 cites W1845975704 @default.
• W2023165823 cites W1902457626 @default.
• W2023165823 cites W1944078087 @default.
• W2023165823 cites W1964525347 @default.
• W2023165823 cites W1967973224 @default.
• W2023165823 cites W1971708565 @default.
• W2023165823 cites W1977851487 @default.
• W2023165823 cites W1979181301 @default.
• W2023165823 cites W1979432835 @default.
• W2023165823 cites W1992144107 @default.
• W2023165823 cites W2011660410 @default.
• W2023165823 cites W2013015490 @default.
• W2023165823 cites W2025346994 @default.
• W2023165823 cites W2026571365 @default.
• W2023165823 cites W2033560950 @default.
• W2023165823 cites W2035213168 @default.
• W2023165823 cites W2037051030 @default.
• W2023165823 cites W2039227742 @default.
• W2023165823 cites W2057701162 @default.
• W2023165823 cites W2058845341 @default.
• W2023165823 cites W2073424135 @default.
• W2023165823 cites W2077822706 @default.
• W2023165823 cites W2086505124 @default.
• W2023165823 cites W2086824623 @default.
• W2023165823 cites W2096322420 @default.
• W2023165823 cites W2102464554 @default.
• W2023165823 cites W2109626244 @default.
• W2023165823 cites W2116243130 @default.
• W2023165823 cites W2139453269 @default.
• W2023165823 cites W2153084076 @default.
• W2023165823 cites W2153739002 @default.
• W2023165823 cites W2156643487 @default.
• W2023165823 cites W2158804540 @default.
• W2023165823 doi "https://doi.org/10.1371/journal.pone.0050667" @default.
• W2023165823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3510171" @default.
• W2023165823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23209805" @default.
• W2023165823 hasPublicationYear "2012" @default.
• W2023165823 type Work @default.
• W2023165823 sameAs 2023165823 @default.
• W2023165823 citedByCount "25" @default.
• W2023165823 countsByYear W20231658232014 @default.
• W2023165823 countsByYear W20231658232015 @default.
• W2023165823 countsByYear W20231658232016 @default.
• W2023165823 countsByYear W20231658232017 @default.
• W2023165823 countsByYear W20231658232018 @default.
• W2023165823 countsByYear W20231658232019 @default.
• W2023165823 countsByYear W20231658232020 @default.
• W2023165823 countsByYear W20231658232022 @default.
• W2023165823 countsByYear W20231658232023 @default.
• W2023165823 crossrefType "journal-article" @default.
• W2023165823 hasAuthorship W2023165823A5009731605 @default.
• W2023165823 hasAuthorship W2023165823A5014820060 @default.
• W2023165823 hasAuthorship W2023165823A5024990785 @default.
• W2023165823 hasAuthorship W2023165823A5027634416 @default.
• W2023165823 hasAuthorship W2023165823A5043648102 @default.
• W2023165823 hasAuthorship W2023165823A5046971648 @default.
• W2023165823 hasAuthorship W2023165823A5059194884 @default.
• W2023165823 hasAuthorship W2023165823A5060457244 @default.
• W2023165823 hasAuthorship W2023165823A5069860717 @default.
• W2023165823 hasAuthorship W2023165823A5084531530 @default.
• W2023165823 hasAuthorship W2023165823A5085944050 @default.
• W2023165823 hasBestOaLocation W20231658231 @default.
• W2023165823 hasConcept C147483822 @default.
• W2023165823 hasConcept C159654299 @default.
• W2023165823 hasConcept C160448771 @default.
• W2023165823 hasConcept C203014093 @default.
• W2023165823 hasConcept C2776090121 @default.
• W2023165823 hasConcept C2778453870 @default.
• W2023165823 hasConcept C2778782520 @default.
• W2023165823 hasConcept C2780931953 @default.
• W2023165823 hasConcept C2781065037 @default.
• W2023165823 hasConcept C43667030 @default.
• W2023165823 hasConcept C523546767 @default.
• W2023165823 hasConcept C54355233 @default.
• W2023165823 hasConcept C86803240 @default.
• W2023165823 hasConcept C8891405 @default.
• W2023165823 hasConcept C89423630 @default.
• W2023165823 hasConcept C90375314 @default.
• W2023165823 hasConceptScore W2023165823C147483822 @default.
• W2023165823 hasConceptScore W2023165823C159654299 @default.
• W2023165823 hasConceptScore W2023165823C160448771 @default.

• next