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• W2023165877 abstract "Abstract 1. 1. The metabolism of choline and sulfocholine (dimethylhydroxyethylsulfonium chloride) in the rat has been compared. 2. 2. Radioactivity from [Me-3H]sulfocholine is incorporated ten times faster into total liver phospholipids than from [35S]sulfocholine. There is no significant difference in the kidney or heart. 3. 3. The sulfocholine metabolites phosphorylsulfocholine, thetin, S-methyl-thioethanol sulfoxide and sulfone have been identified in rat liver. S-Methylthioethanol sulfoxide and sulfone, N-(S-methylthioacetyl)glycine and sulfate were identified in rat urine. 4. 4. Mitochondrial sulfocholine oxidation is much slower than choline oxidation. 5. 5. It is concluded that the lipotropic effect of sulfocholine is due at least in part to oxidation and transmethylation, thus giving rise to phosphatidylcholine. An additional mechanism for demethylation of sulfocholine without primary oxidation must exist. 6. 6. In rats injected with [Me-3H]choline, [Me-3H]sulfocholine or [ 35 S]sulfocholine , the specific activity of CDP-choline was considerably lower than the specific activity of lecithin. These observations are discussed in relation to the known pathways of lecithin biosynthesis." @default.
• W2023165877 created "2016-06-24" @default.
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• W2023165877 date "1969-04-01" @default.
• W2023165877 modified "2023-09-25" @default.
• W2023165877 title "Sulfocholine (dimethylhydroxyethylsulfonium chloride) and choline metabolism in the rat" @default.
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• W2023165877 doi "https://doi.org/10.1016/0005-2760(69)90223-9" @default.
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