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• W2023165881 abstract "Recently, we have described a panel of metastasis-associated antigens in the rat, i.e., of molecules expressed on metastasizing, but not on nonmetastasizing tumor lines. One of these molecules, recognized by the monoclonal antibody D6.1 and named accordingly D6. 1A, was found to be abundantly expressed predominantly on mesenchyme-derived cells. The DNA of the antigen has been isolated and cloned. Surprisingly, the gene product proved to interfere strongly with coagulation. The 1.182-kb cDNA codes for a 235-amino acid long molecule with a 74.2% homology in the nucleotide and a 70% homology in the amino acid sequence to CO-029, a human tumor-associated molecule. According to the distribution of hydrophobic and hydrophilic amino acids, D6.1A belongs to the tetraspanin superfamily. Western blotting of D6.1A-positive metastasizing tumor lines revealed that the D6.1A, like many tetraspanin molecules, is linked to further membrane molecules, one of which could be identified as alpha6beta1 integrin. Transfection of a low-metastasizing tumor cell line with D6.1A cDNA resulted in increased metastatic potential and provided a clue as to the functional role of D6.1A. We noted massive bleeding around the metastases and, possibly as a consequence, local infarctions predominantly in the mesenteric region and all signs of a consumption coagulopathy. By application of the D6.1 antibody the coagulopathy was counterregulated, though not prevented. It has been known for many years that tumor growth and progression is frequently accompanied by thrombotic disorders. Our data suggest that the phenomenon could well be associated with the expression of tetraspanin molecules." @default.
• W2023165881 created "2016-06-24" @default.
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• W2023165881 date "1998-04-06" @default.
• W2023165881 modified "2023-10-13" @default.
• W2023165881 title "Association Between the Rat Homologue of CO-029, a Metastasis-associated Tetraspanin Molecule and Consumption Coagulopathy" @default.
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• W2023165881 cites W1506335912 @default.
• W2023165881 cites W1555648778 @default.
• W2023165881 cites W1572557579 @default.
• W2023165881 cites W1573047394 @default.
• W2023165881 cites W1587916620 @default.
• W2023165881 cites W1590894521 @default.
• W2023165881 cites W1591179447 @default.
• W2023165881 cites W1609871462 @default.
• W2023165881 cites W1831734000 @default.
• W2023165881 cites W1939938623 @default.
• W2023165881 cites W1965181820 @default.
• W2023165881 cites W1967446284 @default.
• W2023165881 cites W1967596423 @default.
• W2023165881 cites W1972231596 @default.
• W2023165881 cites W1974967880 @default.
• W2023165881 cites W1975304761 @default.
• W2023165881 cites W1975343649 @default.
• W2023165881 cites W1976365078 @default.
• W2023165881 cites W1981175218 @default.
• W2023165881 cites W1981822947 @default.
• W2023165881 cites W1985585224 @default.
• W2023165881 cites W1986330147 @default.
• W2023165881 cites W1990311250 @default.
• W2023165881 cites W1990973362 @default.
• W2023165881 cites W1992072758 @default.
• W2023165881 cites W1997202244 @default.
• W2023165881 cites W2009070048 @default.
• W2023165881 cites W2016412376 @default.
• W2023165881 cites W2017767253 @default.
• W2023165881 cites W2018289835 @default.
• W2023165881 cites W2019053861 @default.
• W2023165881 cites W2019931839 @default.
• W2023165881 cites W2020526785 @default.
• W2023165881 cites W2021580435 @default.
• W2023165881 cites W2021680023 @default.
• W2023165881 cites W2024533894 @default.
• W2023165881 cites W2027066304 @default.
• W2023165881 cites W2029092677 @default.
• W2023165881 cites W2034664266 @default.
• W2023165881 cites W2036479695 @default.
• W2023165881 cites W2044338885 @default.
• W2023165881 cites W2046159830 @default.
• W2023165881 cites W2052626837 @default.
• W2023165881 cites W2062684045 @default.
• W2023165881 cites W2064691564 @default.
• W2023165881 cites W2065617621 @default.
• W2023165881 cites W2071167287 @default.
• W2023165881 cites W2073325869 @default.
• W2023165881 cites W2077687259 @default.
• W2023165881 cites W2077863171 @default.
• W2023165881 cites W2087126548 @default.
• W2023165881 cites W2100837269 @default.
• W2023165881 cites W2103062633 @default.
• W2023165881 cites W2104029492 @default.
• W2023165881 cites W2125220487 @default.
• W2023165881 cites W2138270253 @default.
• W2023165881 cites W2139619397 @default.
• W2023165881 cites W2147767883 @default.
• W2023165881 cites W2150642877 @default.
• W2023165881 cites W2150737041 @default.
• W2023165881 cites W2156784364 @default.
• W2023165881 cites W2160006021 @default.
• W2023165881 cites W2164682544 @default.
• W2023165881 cites W2166810441 @default.
• W2023165881 cites W2167661845 @default.
• W2023165881 cites W2189193521 @default.
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• W2023165881 cites W2406402917 @default.
• W2023165881 cites W2410576730 @default.
• W2023165881 cites W2410659882 @default.
• W2023165881 cites W2439052683 @default.
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• W2023165881 doi "https://doi.org/10.1083/jcb.141.1.267" @default.
• W2023165881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2132715" @default.
• W2023165881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9531564" @default.
• W2023165881 hasPublicationYear "1998" @default.
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