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• W2023165901 abstract "En la última década el tratamiento de las hiperlipidemias se ha modificado sustancialmente debido a la introducción de las estatinas, fármacos inhibidores de la enzima hidroximetilglutaril-coenzima A (HMG-CoA) reductasa. Su uso ha sido demostrado como eficaz y seguro en adultos, por lo que podría ser también beneficioso para el tratamiento de las hipercolesterolemias durante la infancia. Hasta el momento, seis han sido utilizadas en población infantil: lovastatina, fluvastatina, pravastatina, simvastatina, atorvastatina y más recientemente rosuvastatina. En algunos de estos estudios el seguimiento ha sido de 3 años y, sobre su uso en la infancia, puede concluirse que a la vez de seguras, son muy eficaces para reducir las concentraciones tanto de colesterol total (CT) como de colesterol de las lipoproteínas de baja densidad (c-LDL) en sangre. In the last decade treatment of hyperlipidemia has changed substantially due to the use of statins, a group of drugs that inhibit the enzyme hydroxymethylglutaryl coenzyme-A-reductase (HMG-CoA reductase). Its use has been proven to be efficient and safe in adults, and could also be of benefit in the treatment of hypercholesterolemia in children. Up to date, six of these drugs have been used in children: lovastatin, fluvastatin, pravastatin, simvastatin, atorvastatin and more recently, rosuvastatin. In some of these studies the follow-up has been up to three years and, as regards their use during childhood, we can conclude that they are safe as well as efficient in reducing the blood levels of total cholesterol (TC) and low-density lipoproteins cholesterol (LDL-C)." @default.
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• W2023165901 date "2008-04-01" @default.
• W2023165901 modified "2023-09-23" @default.
• W2023165901 title "Uso de estatinas durante la infancia" @default.
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• W2023165901 doi "https://doi.org/10.1157/13117712" @default.
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