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• W2023166139 abstract "We report here an effective Pb2+-dependent DNAzyme (8-17 DNAzyme) delivery system based on the water-soluble dendritic polyethylene–cationic poly(p-phenylene ethynylene) for successfully imaging Pb2+ in living cells. For utilizing the 8-17 DNAzyme and its unique ability to catalyze a phosphodiester bond cleavage reaction in the presence of Pb2+, the distinctive conjugated polymer-based polyvalent nanocarrier design manages to load and transport 8-17 DNAzyme across cell membranes, and to realize the fluorescence imaging of Pb2+ in living cells. As shown by the confocal microscopy and flow cytometry observations, the fluorescence of Cy5.5 is obviously activated under the conditions of incubation with Pb2+, compared with the absence of Pb2+. Taken together, the study demonstrates the combination of the molecular-wire effect with “dendrimer effects” on their effective DNAzyme delivery and their cellular imaging Pb2+." @default.
• W2023166139 created "2016-06-24" @default.
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• W2023166139 date "2014-06-27" @default.
• W2023166139 modified "2023-10-17" @default.
• W2023166139 title "Functionalization of cationic poly(p-phenylene ethynylene) with dendritic polyethylene enables efficient DNAzyme delivery for imaging Pb²⁺in living cells" @default.
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• W2023166139 doi "https://doi.org/10.1039/c4tb00680a" @default.
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