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• W2023166575 abstract "Background: Concentrations of the interleukin-1 receptor family member ST2 are powerfully prognostic for adverse outcome in acutely destabilized heart failure (ADHF). However, prior methods for measurement of soluble ST2 (sST2) demonstrated relatively low functional sensitivity and poor analytical precision. We now report the clinical validation of a new, high-sensitivity, high-precision assay for sST2 measurement, the PresageTM ST2 assay. Methods: Among subjects with ADHF from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study, we examined the correlations between prior assays for sST2 (MBL, Woburn, MA) to the PresageTM ST2 assay. In addition, we examined predictors of PresageTM sST2 concentrations in these subjects, and further categorized patients as a function of their sST2 values. Lastly, we examined the performance of the PresageTM ST2 assay for prediction of mortality at 60 days and one year following presentation with ADHF. Results: There was strong correlation between the MBL and PresageTM ST2 assays (rho: 0.91; P <.001). Predictors of PresageTM ST2 concentrations were prior coronary artery disease (P =.02), as well as concentrations of both NT-proBNP and tumor necrosis factor alpha receptors (both P <.001). Patients with an elevated sST2 in the context of ADHF were more likely to have higher concentrations for blood urea nitrogen (P =.004), NT-proBNP, and CRP (both P <.001). sST2 values at presentation with ADHF were higher among decedents compared to survivors at 60 days (76 versus 42 ng/mL; P =.005) and 1 year (67 versus 36 ng/mL; P <.001). For predicting death, sST2 had an area under the curve of 0.76 (P <.001) at 60 days and 0.81 (P <.001) at one year, which were significantly better than NT-proBNP for either time point. A graded association between sST2 concentrations and mortality rate was noted, and in a fully adjusted Cox proportional hazards analysis, an sST2 in excess of 45 ng/mL was strongly predictive of death, independent of other variables of risk (HR=3.10; 95% CI=1.80-5.50; P <.001). Conclusion: The PresageTM assay for measurement of sST2 delivers powerfully prognostic results for short and longer-term mortality prediction in patients with ADHF." @default.
• W2023166575 created "2016-06-24" @default.
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• W2023166575 date "2009-08-01" @default.
• W2023166575 modified "2023-10-14" @default.
• W2023166575 title "Clinical Results for the New PresageTM Soluble ST2 Assay in Acutely Destabilized Heart Failure: Results from the PRIDE Study" @default.
• W2023166575 doi "https://doi.org/10.1016/j.cardfail.2009.06.311" @default.
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