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- W2023166593 abstract "Neurotensin is a peptide present in mammalian CNS and peripheral tissues, which may play a major role in neurotransmission or neuromodulation, subserving diverse physiological functions. We studied the effect of added neurotensin on ATPase activities in synaptosomal membranes isolated from rat cerebral cortex. Neurotensin at 3 × 10−8–3 × 10−6 M concentration decreased 20–44% Na+, K+-ATPase activity but failed to modify Mg2+-ATPase activity; lower neurotensin concentrations (3 × 10−14–3 × 10−10 M) had no effect on enzyme activities. This inhibitory effect was abolished by neurotensin heating, by enzyme preincubation with neurotensin during periods exceeding 10 min, or by adding 1 × 10−6 M SR 48692, a high affinity neurotensin receptor antagonist. Levocabastine, which blocks low affinity neurotensin receptor, failed to alter enzyme inhibition by the peptide. It is suggested that the sodium pump may be a target for neurotensin effects at neuronal level involving the participation of high affinity neurotensin receptor." @default.
- W2023166593 created "2016-06-24" @default.
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- W2023166593 date "2000-04-01" @default.
- W2023166593 modified "2023-10-06" @default.
- W2023166593 title "Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor" @default.
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- W2023166593 doi "https://doi.org/10.1016/s0196-9781(00)00183-2" @default.
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