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- W2023166653 abstract "A simple and rapid quantification method was developed for determining menatetrenone and its epoxide metabolite in human plasma. After a simple protein precipitation with methanol, the analytes were chromatographed on a reversed-phase C(18) column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2 ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30 mg oral dose of menatetrenone." @default.
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- W2023166653 date "2007-09-01" @default.
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- W2023166653 title "Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma" @default.
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- W2023166653 doi "https://doi.org/10.1016/j.jpba.2007.04.028" @default.
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