Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023167306> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2023167306 endingPage "390" @default.
- W2023167306 startingPage "384" @default.
- W2023167306 abstract "Treatment of human carcinoma xenotransplants in athymic mice with recombinant human tumor necrosis factor (rh TNF) causes necrosis mainly in the central parts of the tumors, while peripheral sections remain mitotically active. As tumors are known to be supplied with adequate glucose exclusively in their periphery, the influence of the lack of glucose on the cytotoxic activity of rh TNF was studied. The absence of glucose enhanced the killing of tumor cell lines by rh TNF in tissue culture. Meth-A, a cell line known to be resistant to TNF in vitro but highly sensitive to it in vivo, was readily killed in tissue-culture medium lacking glucose. All non-transformed cell lines tested were found to be resistant to rh TNF, regardless of the presence or absence of glucose. In tumor-bearing mice a reduction of the blood glucose content augmented by insulin led to increased anti-tumor efficiency of rh TNF. The enhanced anti-tumor activity was reflected both in histological sections of the tumor xenotransplants, by extensive central necroses, and by reduction of the tumor volumes. © 1992 Wiley-Liss, Inc." @default.
- W2023167306 created "2016-06-24" @default.
- W2023167306 creator A5044757308 @default.
- W2023167306 creator A5083815662 @default.
- W2023167306 creator A5091645736 @default.
- W2023167306 date "1992-09-30" @default.
- W2023167306 modified "2023-10-18" @default.
- W2023167306 title "Glucose depletion enhances the anti-tumor effect of TNF" @default.
- W2023167306 cites W1546022381 @default.
- W2023167306 cites W1594538340 @default.
- W2023167306 cites W1892859196 @default.
- W2023167306 cites W1972437692 @default.
- W2023167306 cites W1973331161 @default.
- W2023167306 cites W1976990129 @default.
- W2023167306 cites W1989717824 @default.
- W2023167306 cites W1998103617 @default.
- W2023167306 cites W2000507674 @default.
- W2023167306 cites W2002865337 @default.
- W2023167306 cites W2010406277 @default.
- W2023167306 cites W2014444795 @default.
- W2023167306 cites W2019223926 @default.
- W2023167306 cites W2021705268 @default.
- W2023167306 cites W2027457842 @default.
- W2023167306 cites W2047238031 @default.
- W2023167306 cites W2048325240 @default.
- W2023167306 cites W2053441402 @default.
- W2023167306 cites W2057123987 @default.
- W2023167306 cites W2078317160 @default.
- W2023167306 cites W2083726090 @default.
- W2023167306 cites W2084897022 @default.
- W2023167306 cites W2116656764 @default.
- W2023167306 cites W2128031855 @default.
- W2023167306 cites W2499918607 @default.
- W2023167306 doi "https://doi.org/10.1002/ijc.2910520310" @default.
- W2023167306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1399114" @default.
- W2023167306 hasPublicationYear "1992" @default.
- W2023167306 type Work @default.
- W2023167306 sameAs 2023167306 @default.
- W2023167306 citedByCount "10" @default.
- W2023167306 crossrefType "journal-article" @default.
- W2023167306 hasAuthorship W2023167306A5044757308 @default.
- W2023167306 hasAuthorship W2023167306A5083815662 @default.
- W2023167306 hasAuthorship W2023167306A5091645736 @default.
- W2023167306 hasConcept C126322002 @default.
- W2023167306 hasConcept C134018914 @default.
- W2023167306 hasConcept C150903083 @default.
- W2023167306 hasConcept C154317977 @default.
- W2023167306 hasConcept C17991360 @default.
- W2023167306 hasConcept C202751555 @default.
- W2023167306 hasConcept C207001950 @default.
- W2023167306 hasConcept C502942594 @default.
- W2023167306 hasConcept C503630168 @default.
- W2023167306 hasConcept C54355233 @default.
- W2023167306 hasConcept C55493867 @default.
- W2023167306 hasConcept C71924100 @default.
- W2023167306 hasConcept C81885089 @default.
- W2023167306 hasConcept C86803240 @default.
- W2023167306 hasConceptScore W2023167306C126322002 @default.
- W2023167306 hasConceptScore W2023167306C134018914 @default.
- W2023167306 hasConceptScore W2023167306C150903083 @default.
- W2023167306 hasConceptScore W2023167306C154317977 @default.
- W2023167306 hasConceptScore W2023167306C17991360 @default.
- W2023167306 hasConceptScore W2023167306C202751555 @default.
- W2023167306 hasConceptScore W2023167306C207001950 @default.
- W2023167306 hasConceptScore W2023167306C502942594 @default.
- W2023167306 hasConceptScore W2023167306C503630168 @default.
- W2023167306 hasConceptScore W2023167306C54355233 @default.
- W2023167306 hasConceptScore W2023167306C55493867 @default.
- W2023167306 hasConceptScore W2023167306C71924100 @default.
- W2023167306 hasConceptScore W2023167306C81885089 @default.
- W2023167306 hasConceptScore W2023167306C86803240 @default.
- W2023167306 hasIssue "3" @default.
- W2023167306 hasLocation W20231673061 @default.
- W2023167306 hasLocation W20231673062 @default.
- W2023167306 hasOpenAccess W2023167306 @default.
- W2023167306 hasPrimaryLocation W20231673061 @default.
- W2023167306 hasRelatedWork W1528770089 @default.
- W2023167306 hasRelatedWork W1977918131 @default.
- W2023167306 hasRelatedWork W1990717759 @default.
- W2023167306 hasRelatedWork W2000474062 @default.
- W2023167306 hasRelatedWork W2003561519 @default.
- W2023167306 hasRelatedWork W2020692772 @default.
- W2023167306 hasRelatedWork W2059550282 @default.
- W2023167306 hasRelatedWork W2410651038 @default.
- W2023167306 hasRelatedWork W2464301138 @default.
- W2023167306 hasRelatedWork W4313310672 @default.
- W2023167306 hasVolume "52" @default.
- W2023167306 isParatext "false" @default.
- W2023167306 isRetracted "false" @default.
- W2023167306 magId "2023167306" @default.
- W2023167306 workType "article" @default.