FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023167786> ?p ?o ?g. }

• W2023167786 endingPage "66" @default.
• W2023167786 startingPage "62" @default.
• W2023167786 abstract "The PAX5 is essential in normal B-cell lymphopoiesis and deregulation of PAX5 function is believed to contribute to leukemogenesis in B-ALL. We performed a comprehensive study using FISH, G-banding and IHC to identify PAX5 deletion and expression in 102 CD19+ clinical B-ALL cases (79 children and 33 adults) and investigated its relationship with common cytogenetic changes including BCR-ABL1, ETV6-RUNX1 and MLL rearrangements, and CDKN2A deletion. The incidences of translocations and deletions were 2.5% and 10.0% in children, and 0.0% and 18.2% in adults, respectively. The incidence of PAX5 deletion was higher than those of BCR-ABL1 (8.9%) or MLL rearrangements (5.1%) in children and than that of MLL rearrangement (3.1%) in adults. Most patients with PAX5 deletion (83.3% of children and 100.0% of adults with PAX5 deletion) had concurrent CDKN2A deletion. PAX5 deletions were detected both in patients with positive and negative PAX5 expression. In this study, we found that PAX5 is a common target in leukemogenesis of B-ALL along with CDKN2A. Owing to its frequent deletion in B-ALL, PAX5 could be used as one of the molecular markers in diagnosis and monitoring of the disease. No correlation between expression of PAX5 and deletion of PAX5 suggests allele-specific regulation." @default.
• W2023167786 created "2016-06-24" @default.
• W2023167786 creator A5009057220 @default.
• W2023167786 creator A5017873578 @default.
• W2023167786 creator A5045941652 @default.
• W2023167786 creator A5057522489 @default.
• W2023167786 creator A5067685344 @default.
• W2023167786 creator A5070148786 @default.
• W2023167786 creator A5070434251 @default.
• W2023167786 creator A5073284312 @default.
• W2023167786 creator A5073690360 @default.
• W2023167786 creator A5075513508 @default.
• W2023167786 date "2011-06-01" @default.
• W2023167786 modified "2023-10-16" @default.
• W2023167786 title "PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia" @default.
• W2023167786 cites W1506478892 @default.
• W2023167786 cites W1649547160 @default.
• W2023167786 cites W1966384388 @default.
• W2023167786 cites W1984065010 @default.
• W2023167786 cites W1984771935 @default.
• W2023167786 cites W1992161750 @default.
• W2023167786 cites W1995827111 @default.
• W2023167786 cites W2007104998 @default.
• W2023167786 cites W2020020394 @default.
• W2023167786 cites W2023472190 @default.
• W2023167786 cites W2080950303 @default.
• W2023167786 cites W2081870862 @default.
• W2023167786 cites W2094558682 @default.
• W2023167786 cites W2122097597 @default.
• W2023167786 cites W2149237235 @default.
• W2023167786 cites W2153464648 @default.
• W2023167786 doi "https://doi.org/10.1016/j.bcmd.2011.04.003" @default.
• W2023167786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21549623" @default.
• W2023167786 hasPublicationYear "2011" @default.
• W2023167786 type Work @default.
• W2023167786 sameAs 2023167786 @default.
• W2023167786 citedByCount "27" @default.
• W2023167786 countsByYear W20231677862012 @default.
• W2023167786 countsByYear W20231677862013 @default.
• W2023167786 countsByYear W20231677862014 @default.
• W2023167786 countsByYear W20231677862015 @default.
• W2023167786 countsByYear W20231677862016 @default.
• W2023167786 countsByYear W20231677862017 @default.
• W2023167786 countsByYear W20231677862018 @default.
• W2023167786 countsByYear W20231677862019 @default.
• W2023167786 countsByYear W20231677862020 @default.
• W2023167786 countsByYear W20231677862021 @default.
• W2023167786 countsByYear W20231677862022 @default.
• W2023167786 crossrefType "journal-article" @default.
• W2023167786 hasAuthorship W2023167786A5009057220 @default.
• W2023167786 hasAuthorship W2023167786A5017873578 @default.
• W2023167786 hasAuthorship W2023167786A5045941652 @default.
• W2023167786 hasAuthorship W2023167786A5057522489 @default.
• W2023167786 hasAuthorship W2023167786A5067685344 @default.
• W2023167786 hasAuthorship W2023167786A5070148786 @default.
• W2023167786 hasAuthorship W2023167786A5070434251 @default.
• W2023167786 hasAuthorship W2023167786A5073284312 @default.
• W2023167786 hasAuthorship W2023167786A5073690360 @default.
• W2023167786 hasAuthorship W2023167786A5075513508 @default.
• W2023167786 hasConcept C104317684 @default.
• W2023167786 hasConcept C138626823 @default.
• W2023167786 hasConcept C147483822 @default.
• W2023167786 hasConcept C153911025 @default.
• W2023167786 hasConcept C159654299 @default.
• W2023167786 hasConcept C2778453870 @default.
• W2023167786 hasConcept C2778957590 @default.
• W2023167786 hasConcept C2780265364 @default.
• W2023167786 hasConcept C29447677 @default.
• W2023167786 hasConcept C43907098 @default.
• W2023167786 hasConcept C502942594 @default.
• W2023167786 hasConcept C54355233 @default.
• W2023167786 hasConcept C86803240 @default.
• W2023167786 hasConceptScore W2023167786C104317684 @default.
• W2023167786 hasConceptScore W2023167786C138626823 @default.
• W2023167786 hasConceptScore W2023167786C147483822 @default.
• W2023167786 hasConceptScore W2023167786C153911025 @default.
• W2023167786 hasConceptScore W2023167786C159654299 @default.
• W2023167786 hasConceptScore W2023167786C2778453870 @default.
• W2023167786 hasConceptScore W2023167786C2778957590 @default.
• W2023167786 hasConceptScore W2023167786C2780265364 @default.
• W2023167786 hasConceptScore W2023167786C29447677 @default.
• W2023167786 hasConceptScore W2023167786C43907098 @default.
• W2023167786 hasConceptScore W2023167786C502942594 @default.
• W2023167786 hasConceptScore W2023167786C54355233 @default.
• W2023167786 hasConceptScore W2023167786C86803240 @default.
• W2023167786 hasFunder F4320322120 @default.
• W2023167786 hasFunder F4320322348 @default.
• W2023167786 hasFunder F4320322349 @default.
• W2023167786 hasFunder F4320324544 @default.
• W2023167786 hasIssue "1" @default.
• W2023167786 hasLocation W20231677861 @default.
• W2023167786 hasLocation W20231677862 @default.
• W2023167786 hasOpenAccess W2023167786 @default.
• W2023167786 hasPrimaryLocation W20231677861 @default.
• W2023167786 hasRelatedWork W1632996825 @default.
• W2023167786 hasRelatedWork W2023167786 @default.
• W2023167786 hasRelatedWork W2093637849 @default.
• W2023167786 hasRelatedWork W2107227659 @default.

• next