FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023167871> ?p ?o ?g. }

• W2023167871 endingPage "23" @default.
• W2023167871 startingPage "15" @default.
• W2023167871 abstract "Neutralizing antibodies directed against measles virus (MV) surface glycoproteins prevent viral attachment and entry through the natural receptors. H protein specific IgG can enhance MV infectivity in macrophages via Fcγ receptor (FcγR)-dependent mechanism. H-specific IgM, anti-F antibodies and complement cascade activation are protective against antibody-mediated enhancement of MV infection. However, protective role of anti-H IgG against antibody-enhanced infection is not well understood. Here we designed a set of experiments to test the protective effect of H-specific IgG against FcγR-mediated infection in microglial cells. Microglial cells are also potential target of the antibody-mediated enhancement and spread of MV infection in the central nervous system. A partially neutralizing IgG monoclonal antibody (MAb) CL55, specific for MV H protein, at 10 μg/ml enhanced MV infection in mouse microglial cells by 13-14-fold. Infection-enhancing antibody concentrations induced large multinucleated syncytia formation 48-72 h post-inoculation. We generated anti-H IgG MAb 20H6 with a strong neutralization capacity >1:80,000 at 1mg/ml concentration in MV plaque-reduction neutralization assay. In contrast to the partially protective MAb CL55, enhancement of MV infectivity by MAb 20H6 required dilutions below the 1:120 serum titer considered protective against measles infection in humans. At a concentration of 10 μg/ml MAb 20H6 exhibited a dominant protective effect and prevented MAb CL55-mediated enhancement of MV infection and virus-mediated fusion. These results indicate that neutralization capacity of the H-specific IgG determines the balance between antibody enhancement and protection against MV infection in microglial cells." @default.
• W2023167871 created "2016-06-24" @default.
• W2023167871 creator A5017494786 @default.
• W2023167871 creator A5028587627 @default.
• W2023167871 creator A5051663238 @default.
• W2023167871 creator A5058119708 @default.
• W2023167871 creator A5087156710 @default.
• W2023167871 creator A5090310890 @default.
• W2023167871 date "2013-03-01" @default.
• W2023167871 modified "2023-10-14" @default.
• W2023167871 title "Neutralization capacity of measles virus H protein specific IgG determines the balance between antibody-enhanced infectivity and protection in microglial cells" @default.
• W2023167871 cites W1581511516 @default.
• W2023167871 cites W1919971299 @default.
• W2023167871 cites W1966278779 @default.
• W2023167871 cites W1968895408 @default.
• W2023167871 cites W1970121767 @default.
• W2023167871 cites W2005162396 @default.
• W2023167871 cites W2006161766 @default.
• W2023167871 cites W2010654586 @default.
• W2023167871 cites W2011361113 @default.
• W2023167871 cites W2011873059 @default.
• W2023167871 cites W2025537188 @default.
• W2023167871 cites W2030522563 @default.
• W2023167871 cites W2040182130 @default.
• W2023167871 cites W2041233743 @default.
• W2023167871 cites W2047895583 @default.
• W2023167871 cites W2049915467 @default.
• W2023167871 cites W2051110761 @default.
• W2023167871 cites W2052669763 @default.
• W2023167871 cites W2055495528 @default.
• W2023167871 cites W2055536018 @default.
• W2023167871 cites W2056289798 @default.
• W2023167871 cites W2065486680 @default.
• W2023167871 cites W2065954860 @default.
• W2023167871 cites W207109113 @default.
• W2023167871 cites W2080853135 @default.
• W2023167871 cites W2083294642 @default.
• W2023167871 cites W2086278026 @default.
• W2023167871 cites W2087771052 @default.
• W2023167871 cites W2093424381 @default.
• W2023167871 cites W2093780636 @default.
• W2023167871 cites W2102082606 @default.
• W2023167871 cites W2116345938 @default.
• W2023167871 cites W2133920480 @default.
• W2023167871 cites W2137257347 @default.
• W2023167871 cites W2142916148 @default.
• W2023167871 cites W2145310902 @default.
• W2023167871 cites W2160653307 @default.
• W2023167871 doi "https://doi.org/10.1016/j.virusres.2012.12.002" @default.
• W2023167871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3612881" @default.
• W2023167871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23266401" @default.
• W2023167871 hasPublicationYear "2013" @default.
• W2023167871 type Work @default.
• W2023167871 sameAs 2023167871 @default.
• W2023167871 citedByCount "11" @default.
• W2023167871 countsByYear W20231678712013 @default.
• W2023167871 countsByYear W20231678712014 @default.
• W2023167871 countsByYear W20231678712018 @default.
• W2023167871 countsByYear W20231678712021 @default.
• W2023167871 countsByYear W20231678712022 @default.
• W2023167871 crossrefType "journal-article" @default.
• W2023167871 hasAuthorship W2023167871A5017494786 @default.
• W2023167871 hasAuthorship W2023167871A5028587627 @default.
• W2023167871 hasAuthorship W2023167871A5051663238 @default.
• W2023167871 hasAuthorship W2023167871A5058119708 @default.
• W2023167871 hasAuthorship W2023167871A5087156710 @default.
• W2023167871 hasAuthorship W2023167871A5090310890 @default.
• W2023167871 hasBestOaLocation W20231678712 @default.
• W2023167871 hasConcept C106358424 @default.
• W2023167871 hasConcept C140704245 @default.
• W2023167871 hasConcept C14086860 @default.
• W2023167871 hasConcept C153911025 @default.
• W2023167871 hasConcept C159047783 @default.
• W2023167871 hasConcept C159654299 @default.
• W2023167871 hasConcept C196594336 @default.
• W2023167871 hasConcept C203014093 @default.
• W2023167871 hasConcept C22070199 @default.
• W2023167871 hasConcept C2522874641 @default.
• W2023167871 hasConcept C2776264772 @default.
• W2023167871 hasConcept C2776438120 @default.
• W2023167871 hasConcept C2778199166 @default.
• W2023167871 hasConcept C2779261636 @default.
• W2023167871 hasConcept C2780898057 @default.
• W2023167871 hasConcept C542903549 @default.
• W2023167871 hasConcept C86803240 @default.
• W2023167871 hasConceptScore W2023167871C106358424 @default.
• W2023167871 hasConceptScore W2023167871C140704245 @default.
• W2023167871 hasConceptScore W2023167871C14086860 @default.
• W2023167871 hasConceptScore W2023167871C153911025 @default.
• W2023167871 hasConceptScore W2023167871C159047783 @default.
• W2023167871 hasConceptScore W2023167871C159654299 @default.
• W2023167871 hasConceptScore W2023167871C196594336 @default.
• W2023167871 hasConceptScore W2023167871C203014093 @default.
• W2023167871 hasConceptScore W2023167871C22070199 @default.
• W2023167871 hasConceptScore W2023167871C2522874641 @default.
• W2023167871 hasConceptScore W2023167871C2776264772 @default.
• W2023167871 hasConceptScore W2023167871C2776438120 @default.
• W2023167871 hasConceptScore W2023167871C2778199166 @default.

• next