FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023168478> ?p ?o ?g. }

• W2023168478 endingPage "434" @default.
• W2023168478 startingPage "415" @default.
• W2023168478 abstract "Multicellular organisms shape development and remove aberrant cells by programmed cell death (apoptosis). Because defective cell death (too little or too much) is implicated in various diseases (like cancer and autoimmunity), understanding how apoptosis is regulated is an important goal of molecular cell biologists. To this end, we propose a mathematical model of the intrinsic apoptotic pathway that captures three key dynamical features: a signal threshold to elicit cell death, irreversible commitment to the response, and a time delay that is inversely proportional to signal strength. Subdividing the intrinsic pathway into three modules (initiator, amplifier, executioner), we use computer simulation and bifurcation theory to attribute signal threshold and time delay to positive feedback in the initiator module and irreversible commitment to positive feedback in the executioner module. The model accounts for the behavior of mutants deficient in various genes and is used to design experiments that would test its basic assumptions. Finally, we apply the model to study p53-induced cellular responses to DNA damage. Cells first undergo cell cycle arrest and DNA repair, and then apoptosis if the damage is beyond repair. The model ascribes this cell-fate transition to a transformation of p53 from helper to killer forms." @default.
• W2023168478 created "2016-06-24" @default.
• W2023168478 creator A5003112405 @default.
• W2023168478 creator A5028908910 @default.
• W2023168478 creator A5035808792 @default.
• W2023168478 date "2009-07-01" @default.
• W2023168478 modified "2023-10-12" @default.
• W2023168478 title "Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death" @default.
• W2023168478 cites W1507812324 @default.
• W2023168478 cites W1509012393 @default.
• W2023168478 cites W1520563041 @default.
• W2023168478 cites W1604468403 @default.
• W2023168478 cites W172276776 @default.
• W2023168478 cites W1963501271 @default.
• W2023168478 cites W1964037688 @default.
• W2023168478 cites W1964742508 @default.
• W2023168478 cites W1968006317 @default.
• W2023168478 cites W1976842123 @default.
• W2023168478 cites W1976873804 @default.
• W2023168478 cites W1989903496 @default.
• W2023168478 cites W1992989336 @default.
• W2023168478 cites W1996861281 @default.
• W2023168478 cites W1999014427 @default.
• W2023168478 cites W2002735482 @default.
• W2023168478 cites W2005909927 @default.
• W2023168478 cites W2008257691 @default.
• W2023168478 cites W2008841394 @default.
• W2023168478 cites W2008887283 @default.
• W2023168478 cites W2009183786 @default.
• W2023168478 cites W2009348177 @default.
• W2023168478 cites W2009845042 @default.
• W2023168478 cites W2011007189 @default.
• W2023168478 cites W2014999693 @default.
• W2023168478 cites W2018252885 @default.
• W2023168478 cites W2020661522 @default.
• W2023168478 cites W2021051229 @default.
• W2023168478 cites W2024105041 @default.
• W2023168478 cites W2025476423 @default.
• W2023168478 cites W2027533135 @default.
• W2023168478 cites W2034269086 @default.
• W2023168478 cites W2038305733 @default.
• W2023168478 cites W2042990867 @default.
• W2023168478 cites W2047160541 @default.
• W2023168478 cites W2049225749 @default.
• W2023168478 cites W2051258629 @default.
• W2023168478 cites W2057428268 @default.
• W2023168478 cites W2061019845 @default.
• W2023168478 cites W2063107060 @default.
• W2023168478 cites W2065372463 @default.
• W2023168478 cites W2073028327 @default.
• W2023168478 cites W2074501845 @default.
• W2023168478 cites W2077206871 @default.
• W2023168478 cites W2077229666 @default.
• W2023168478 cites W2087450028 @default.
• W2023168478 cites W2087764283 @default.
• W2023168478 cites W2088762003 @default.
• W2023168478 cites W2089442061 @default.
• W2023168478 cites W2089809684 @default.
• W2023168478 cites W2093730092 @default.
• W2023168478 cites W2097531829 @default.
• W2023168478 cites W2098975407 @default.
• W2023168478 cites W2099791142 @default.
• W2023168478 cites W2105896701 @default.
• W2023168478 cites W2113999599 @default.
• W2023168478 cites W2116875795 @default.
• W2023168478 cites W2120531171 @default.
• W2023168478 cites W2131532199 @default.
• W2023168478 cites W2136269288 @default.
• W2023168478 cites W2141997480 @default.
• W2023168478 cites W2144702196 @default.
• W2023168478 cites W2145006562 @default.
• W2023168478 cites W2146977885 @default.
• W2023168478 cites W2150750144 @default.
• W2023168478 cites W2152585118 @default.
• W2023168478 cites W2152826290 @default.
• W2023168478 cites W2159583680 @default.
• W2023168478 cites W2166668167 @default.
• W2023168478 cites W2168639189 @default.
• W2023168478 cites W2169205569 @default.
• W2023168478 cites W2313997600 @default.
• W2023168478 cites W2317926428 @default.
• W2023168478 doi "https://doi.org/10.1016/j.bpj.2009.04.053" @default.
• W2023168478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711321" @default.
• W2023168478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19619456" @default.
• W2023168478 hasPublicationYear "2009" @default.
• W2023168478 type Work @default.
• W2023168478 sameAs 2023168478 @default.
• W2023168478 citedByCount "88" @default.
• W2023168478 countsByYear W20231684782012 @default.
• W2023168478 countsByYear W20231684782013 @default.
• W2023168478 countsByYear W20231684782014 @default.
• W2023168478 countsByYear W20231684782015 @default.
• W2023168478 countsByYear W20231684782016 @default.
• W2023168478 countsByYear W20231684782017 @default.
• W2023168478 countsByYear W20231684782018 @default.
• W2023168478 countsByYear W20231684782019 @default.
• W2023168478 countsByYear W20231684782020 @default.
• W2023168478 countsByYear W20231684782021 @default.

• next