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W2023169579 abstract "Anaplastic large cell lymphomas (ALCL) often express the oncoprotein NPM-ALK. This study shows that the activator protein 1 family members JUN and JUNB promote lymphoma development through platelet-derived growth factor receptor-β (PDGFRB). Inhibition of PDGFRB prolonged survival of NPM-ALK transgenic mice and increased the efficacy of an ALK-specific inhibitor against transplanted NPM-ALK tumors. Inhibition of PDGFR in a patient with ALCL also resulted in rapid, complete and sustained remission. Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in children and young adults. ALCLs frequently carry a chromosomal translocation that results in expression of the oncoprotein nucleophosmin–anaplastic lymphoma kinase (NPM-ALK). The key molecular downstream events required for NPM-ALK–triggered lymphoma growth have been only partly unveiled. Here we show that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK–triggered lymphomagenesis. Therapeutic inhibition of PDGFRB markedly prolonged survival of NPM-ALK transgenic mice and increased the efficacy of an ALK-specific inhibitor in transplanted NPM-ALK tumors. Notably, inhibition of PDGFRA and PDGFRB in a patient with refractory late-stage NPM-ALK+ ALCL resulted in rapid, complete and sustained remission. Together, our data identify PDGFRB as a previously unknown JUN and JUNB target that could be a highly effective therapy for ALCL." @default.
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W2023169579 date "2012-10-14" @default.
W2023169579 modified "2023-10-16" @default.
W2023169579 title "PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas" @default.
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W2023169579 cites W1974453246 @default.
W2023169579 cites W1981101983 @default.
W2023169579 cites W1990152951 @default.
W2023169579 cites W1990487163 @default.
W2023169579 cites W1991092798 @default.
W2023169579 cites W1997476230 @default.
W2023169579 cites W1998334213 @default.
W2023169579 cites W2022354436 @default.
W2023169579 cites W2028774918 @default.
W2023169579 cites W2034862875 @default.
W2023169579 cites W2035282066 @default.
W2023169579 cites W2038586807 @default.
W2023169579 cites W2055402151 @default.
W2023169579 cites W2060275730 @default.
W2023169579 cites W2069140859 @default.
W2023169579 cites W2070130348 @default.
W2023169579 cites W2077642701 @default.
W2023169579 cites W2079116568 @default.
W2023169579 cites W2092048234 @default.
W2023169579 cites W2093116780 @default.
W2023169579 cites W2093710793 @default.
W2023169579 cites W2095324960 @default.
W2023169579 cites W2098180441 @default.
W2023169579 cites W2101491950 @default.
W2023169579 cites W2104830962 @default.
W2023169579 cites W2128016314 @default.
W2023169579 cites W2135387401 @default.
W2023169579 cites W2140502641 @default.
W2023169579 cites W2150953357 @default.
W2023169579 cites W2153550523 @default.
W2023169579 cites W2155214429 @default.
W2023169579 cites W2165022781 @default.
W2023169579 cites W2171628252 @default.
W2023169579 cites W2277029715 @default.
W2023169579 cites W2325867347 @default.
W2023169579 cites W88081109 @default.
W2023169579 doi "https://doi.org/10.1038/nm.2966" @default.
W2023169579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064464" @default.
W2023169579 hasPublicationYear "2012" @default.
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