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- W2023169719 abstract "The photodynamic action of protoporphyrin on erythrocytes of patients with erythropoietic protoporphyria and on sensitized normal red blood cells leads to K+ loss and Na+ gain, resulting finally in colloid osmotic hemolysis. To elucidate the pathochemical background of this process, the ATP and glutathione-producing metabolic systems and the activity of other cellular enzymes was studied during irradiation, in the prelytic period. The glucose consumption, intracellular ATP level and catalase activity were not influenced by the photochemical process, whereas the cellular glutathione concentration decreased during irradiation. The activity of cellular acetylcholinesterase and of membrane ATPase decreased in the prelytic period, the (Na+ + K+)-dependent ATPase being more sensitive than the Mg2+-stimulated ATPase. Measurements of 86Rb+ uptake demonstrated a decreasing active Rb+ transport with a concomitant increase of passive Rb+ permeability during irradiation. The results indicated that the cellular membrane is presumably the primary target of the protoporphyrin-induced photodynamic process." @default.
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- W2023169719 date "1971-06-01" @default.
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- W2023169719 title "Metabolic aspects of the photodynamic effect of protoporphyrin in protoporphyria and in normal red blood cells" @default.
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- W2023169719 doi "https://doi.org/10.1016/0009-8981(71)90269-5" @default.
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