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• W2023169834 startingPage "92" @default.
• W2023169834 abstract "Silymarin commonly known for its hepatoprotective effect is reported to show protection against 6-hydroxydopamine-induced neurotoxicity. Silibinin forms the major active constituent of silymarin. Therefore, the neuroprotective effect of silibinin (50, 100 and 200 mg/kg) was evaluated in the unilaterally injected 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic neurotoxicity in male rats. A battery of tests such as elevated plus maze (EPM), narrow beam walk, open field, bar catalepsy, grip strength, and foot print analysis was performed to evaluate the behavioral symptoms of striatal dopaminergic toxicity. Furthermore, the mechanism of action of silibinin was investigated by evaluating the mitochondrial complex enzyme activities, mitochondrial integrity and oxidative status. Striatal caspase-3 and NFκB were expressed to evaluate the effect of silibinin on apoptosis and inflammation respectively. Silibinin (100 and 200 mg/kg) protected against MPP(+)-induced dopamine depletion in striatum. Silibinin reversed MPP(+)-induced decrease in transfer latency indicating memory consolidation in the EPM test. Silibinin (100 and 200 mg/kg) attenuated MPP(+)-induced motor deficits, such as fine motor movements and gait. MPP(+)-induced mitochondrial dysfunction, loss of integrity and oxidative stress were attenuated by silibinin. Silibinin decreased striatal caspase-3 and NFκB expression indicating potential anti-apoptotic and anti-inflammatory effects respectively. Hence, silibinin exhibited neuroprotective effect in the MPP(+) induced striatal toxicity augmenting dopamine levels. The mechanism of action may be linked to maintenance of mitochondrial bioenergetics and integrity apart from anti-apoptotic and anti-inflammatory activities." @default.
• W2023169834 created "2016-06-24" @default.
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• W2023169834 date "2014-02-01" @default.
• W2023169834 modified "2023-10-18" @default.
• W2023169834 title "Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats" @default.
• W2023169834 cites W146759131 @default.
• W2023169834 cites W1520955829 @default.
• W2023169834 cites W1529592271 @default.
• W2023169834 cites W1533338174 @default.
• W2023169834 cites W1586947032 @default.
• W2023169834 cites W1775749144 @default.
• W2023169834 cites W1914379946 @default.
• W2023169834 cites W1964780858 @default.
• W2023169834 cites W1969750257 @default.
• W2023169834 cites W1979513033 @default.
• W2023169834 cites W1981255119 @default.
• W2023169834 cites W1983107467 @default.
• W2023169834 cites W1983310681 @default.
• W2023169834 cites W1984285213 @default.
• W2023169834 cites W1984993711 @default.
• W2023169834 cites W1986671246 @default.
• W2023169834 cites W1989405078 @default.
• W2023169834 cites W1989502324 @default.
• W2023169834 cites W1990802251 @default.
• W2023169834 cites W1993765879 @default.
• W2023169834 cites W1994017777 @default.
• W2023169834 cites W1999228896 @default.
• W2023169834 cites W2002703101 @default.
• W2023169834 cites W2003017246 @default.
• W2023169834 cites W2004340905 @default.
• W2023169834 cites W2005089402 @default.
• W2023169834 cites W2006696253 @default.
• W2023169834 cites W2007293163 @default.
• W2023169834 cites W2008434646 @default.
• W2023169834 cites W2011162934 @default.
• W2023169834 cites W2021057071 @default.
• W2023169834 cites W2023618561 @default.
• W2023169834 cites W2026052382 @default.
• W2023169834 cites W2026305160 @default.
• W2023169834 cites W2030406677 @default.
• W2023169834 cites W2030488297 @default.
• W2023169834 cites W2037072780 @default.
• W2023169834 cites W2038089968 @default.
• W2023169834 cites W2049144486 @default.
• W2023169834 cites W2055308573 @default.
• W2023169834 cites W2065318828 @default.
• W2023169834 cites W2067313980 @default.
• W2023169834 cites W2067671016 @default.
• W2023169834 cites W2071968255 @default.
• W2023169834 cites W2072670326 @default.
• W2023169834 cites W2073038323 @default.
• W2023169834 cites W2077152493 @default.
• W2023169834 cites W2078837477 @default.
• W2023169834 cites W2079547714 @default.
• W2023169834 cites W2086150553 @default.
• W2023169834 cites W2086455336 @default.
• W2023169834 cites W2091449183 @default.
• W2023169834 cites W2091485211 @default.
• W2023169834 cites W2092204341 @default.
• W2023169834 cites W2101980327 @default.
• W2023169834 cites W2102983397 @default.
• W2023169834 cites W2111065594 @default.
• W2023169834 cites W2114049362 @default.
• W2023169834 cites W2140075873 @default.
• W2023169834 cites W2153435210 @default.
• W2023169834 cites W2168162647 @default.
• W2023169834 cites W2168560579 @default.
• W2023169834 cites W2171654279 @default.
• W2023169834 cites W2469249458 @default.
• W2023169834 cites W2792448780 @default.
• W2023169834 cites W4210995338 @default.
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• W2023169834 doi "https://doi.org/10.1016/j.pbb.2013.12.008" @default.
• W2023169834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24345573" @default.
• W2023169834 hasPublicationYear "2014" @default.
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